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Aortic Root Calcification Score as an Independent Factor for Predicting Major Adverse Cardiac Events in Familial Hypercholesterolemia

Aim: The aims of this study were: 1) to determine whether the accumulation of aortic root calcification (ARC) assessed using coronary computed tomography angiography (CCTA) can predict future cardiovascular events, and 2) to estimate the onset and progression of ARC in patients with familial hyperch...

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Autores principales: Okada, Hirofumi, Tada, Hayato, Hayashi, Kenshi, Kawashima, Hiroki, Takata, Tadanori, Sakata, Kenji, Nohara, Atsushi, Mabuchi, Hiroshi, Yamagishi, Masakazu, Kawashiri, Masa-aki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Atherosclerosis Society 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055038/
https://www.ncbi.nlm.nih.gov/pubmed/29321389
http://dx.doi.org/10.5551/jat.42705
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author Okada, Hirofumi
Tada, Hayato
Hayashi, Kenshi
Kawashima, Hiroki
Takata, Tadanori
Sakata, Kenji
Nohara, Atsushi
Mabuchi, Hiroshi
Yamagishi, Masakazu
Kawashiri, Masa-aki
author_facet Okada, Hirofumi
Tada, Hayato
Hayashi, Kenshi
Kawashima, Hiroki
Takata, Tadanori
Sakata, Kenji
Nohara, Atsushi
Mabuchi, Hiroshi
Yamagishi, Masakazu
Kawashiri, Masa-aki
author_sort Okada, Hirofumi
collection PubMed
description Aim: The aims of this study were: 1) to determine whether the accumulation of aortic root calcification (ARC) assessed using coronary computed tomography angiography (CCTA) can predict future cardiovascular events, and 2) to estimate the onset and progression of ARC in patients with familial hypercholesterolemia (FH). Methods: One hundred thirteen consecutive Japanese patients with heterozygous FH (male = 54, mean age = 52.1 ± 15.6 years, mean LDL-C = 299.0 ± 94.6 mg/dL), without known coronary artery disease, who underwent 64-detector row CCTA were retrospectively evaluated. ARC was defined as the presence of calcium at the aortic root. The extent of ARC was expressed in Agatston units as the ARC-score. Major adverse cardiac events (MACE) were defined as either cardiac death, ST elevated myocardial infarction (STEMI), non-ST elevated myocardial infarction (NSTEMI), unstable angina pectoris (UAP), planned percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG), or stroke. The periods to MACE were estimated using multivariate logistic regression analysis. Results: During the follow-up period (median 1635 days), 19 instances of MACE occurred. Multivariate logistic regression analysis revealed that ARC was a significant independent predictor of MACE (OR= 1.48; 95% CI 1.11–1.87, p < 0.001, respectively). The regression equations were Y= 0.09X − 1.59 (R(2) = 0.34, p < 0.001) in males and Y = 0.08X − 1.60 (R(2) = 0.13, p < 0. 05) in females. Conclusions: ARC was significantly associated with future MACE in Japanese patients with heterozygous FH. ARC may start to develop, on average, at 17.4 and 19.7 years of age in males and females, respectively, with heterozygous FH.
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spelling pubmed-60550382018-07-23 Aortic Root Calcification Score as an Independent Factor for Predicting Major Adverse Cardiac Events in Familial Hypercholesterolemia Okada, Hirofumi Tada, Hayato Hayashi, Kenshi Kawashima, Hiroki Takata, Tadanori Sakata, Kenji Nohara, Atsushi Mabuchi, Hiroshi Yamagishi, Masakazu Kawashiri, Masa-aki J Atheroscler Thromb Original Article Aim: The aims of this study were: 1) to determine whether the accumulation of aortic root calcification (ARC) assessed using coronary computed tomography angiography (CCTA) can predict future cardiovascular events, and 2) to estimate the onset and progression of ARC in patients with familial hypercholesterolemia (FH). Methods: One hundred thirteen consecutive Japanese patients with heterozygous FH (male = 54, mean age = 52.1 ± 15.6 years, mean LDL-C = 299.0 ± 94.6 mg/dL), without known coronary artery disease, who underwent 64-detector row CCTA were retrospectively evaluated. ARC was defined as the presence of calcium at the aortic root. The extent of ARC was expressed in Agatston units as the ARC-score. Major adverse cardiac events (MACE) were defined as either cardiac death, ST elevated myocardial infarction (STEMI), non-ST elevated myocardial infarction (NSTEMI), unstable angina pectoris (UAP), planned percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG), or stroke. The periods to MACE were estimated using multivariate logistic regression analysis. Results: During the follow-up period (median 1635 days), 19 instances of MACE occurred. Multivariate logistic regression analysis revealed that ARC was a significant independent predictor of MACE (OR= 1.48; 95% CI 1.11–1.87, p < 0.001, respectively). The regression equations were Y= 0.09X − 1.59 (R(2) = 0.34, p < 0.001) in males and Y = 0.08X − 1.60 (R(2) = 0.13, p < 0. 05) in females. Conclusions: ARC was significantly associated with future MACE in Japanese patients with heterozygous FH. ARC may start to develop, on average, at 17.4 and 19.7 years of age in males and females, respectively, with heterozygous FH. Japan Atherosclerosis Society 2018-07-01 /pmc/articles/PMC6055038/ /pubmed/29321389 http://dx.doi.org/10.5551/jat.42705 Text en 2018 Japan Atherosclerosis Society This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Original Article
Okada, Hirofumi
Tada, Hayato
Hayashi, Kenshi
Kawashima, Hiroki
Takata, Tadanori
Sakata, Kenji
Nohara, Atsushi
Mabuchi, Hiroshi
Yamagishi, Masakazu
Kawashiri, Masa-aki
Aortic Root Calcification Score as an Independent Factor for Predicting Major Adverse Cardiac Events in Familial Hypercholesterolemia
title Aortic Root Calcification Score as an Independent Factor for Predicting Major Adverse Cardiac Events in Familial Hypercholesterolemia
title_full Aortic Root Calcification Score as an Independent Factor for Predicting Major Adverse Cardiac Events in Familial Hypercholesterolemia
title_fullStr Aortic Root Calcification Score as an Independent Factor for Predicting Major Adverse Cardiac Events in Familial Hypercholesterolemia
title_full_unstemmed Aortic Root Calcification Score as an Independent Factor for Predicting Major Adverse Cardiac Events in Familial Hypercholesterolemia
title_short Aortic Root Calcification Score as an Independent Factor for Predicting Major Adverse Cardiac Events in Familial Hypercholesterolemia
title_sort aortic root calcification score as an independent factor for predicting major adverse cardiac events in familial hypercholesterolemia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055038/
https://www.ncbi.nlm.nih.gov/pubmed/29321389
http://dx.doi.org/10.5551/jat.42705
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