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Aortic Root Calcification Score as an Independent Factor for Predicting Major Adverse Cardiac Events in Familial Hypercholesterolemia
Aim: The aims of this study were: 1) to determine whether the accumulation of aortic root calcification (ARC) assessed using coronary computed tomography angiography (CCTA) can predict future cardiovascular events, and 2) to estimate the onset and progression of ARC in patients with familial hyperch...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japan Atherosclerosis Society
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055038/ https://www.ncbi.nlm.nih.gov/pubmed/29321389 http://dx.doi.org/10.5551/jat.42705 |
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author | Okada, Hirofumi Tada, Hayato Hayashi, Kenshi Kawashima, Hiroki Takata, Tadanori Sakata, Kenji Nohara, Atsushi Mabuchi, Hiroshi Yamagishi, Masakazu Kawashiri, Masa-aki |
author_facet | Okada, Hirofumi Tada, Hayato Hayashi, Kenshi Kawashima, Hiroki Takata, Tadanori Sakata, Kenji Nohara, Atsushi Mabuchi, Hiroshi Yamagishi, Masakazu Kawashiri, Masa-aki |
author_sort | Okada, Hirofumi |
collection | PubMed |
description | Aim: The aims of this study were: 1) to determine whether the accumulation of aortic root calcification (ARC) assessed using coronary computed tomography angiography (CCTA) can predict future cardiovascular events, and 2) to estimate the onset and progression of ARC in patients with familial hypercholesterolemia (FH). Methods: One hundred thirteen consecutive Japanese patients with heterozygous FH (male = 54, mean age = 52.1 ± 15.6 years, mean LDL-C = 299.0 ± 94.6 mg/dL), without known coronary artery disease, who underwent 64-detector row CCTA were retrospectively evaluated. ARC was defined as the presence of calcium at the aortic root. The extent of ARC was expressed in Agatston units as the ARC-score. Major adverse cardiac events (MACE) were defined as either cardiac death, ST elevated myocardial infarction (STEMI), non-ST elevated myocardial infarction (NSTEMI), unstable angina pectoris (UAP), planned percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG), or stroke. The periods to MACE were estimated using multivariate logistic regression analysis. Results: During the follow-up period (median 1635 days), 19 instances of MACE occurred. Multivariate logistic regression analysis revealed that ARC was a significant independent predictor of MACE (OR= 1.48; 95% CI 1.11–1.87, p < 0.001, respectively). The regression equations were Y= 0.09X − 1.59 (R(2) = 0.34, p < 0.001) in males and Y = 0.08X − 1.60 (R(2) = 0.13, p < 0. 05) in females. Conclusions: ARC was significantly associated with future MACE in Japanese patients with heterozygous FH. ARC may start to develop, on average, at 17.4 and 19.7 years of age in males and females, respectively, with heterozygous FH. |
format | Online Article Text |
id | pubmed-6055038 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Japan Atherosclerosis Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-60550382018-07-23 Aortic Root Calcification Score as an Independent Factor for Predicting Major Adverse Cardiac Events in Familial Hypercholesterolemia Okada, Hirofumi Tada, Hayato Hayashi, Kenshi Kawashima, Hiroki Takata, Tadanori Sakata, Kenji Nohara, Atsushi Mabuchi, Hiroshi Yamagishi, Masakazu Kawashiri, Masa-aki J Atheroscler Thromb Original Article Aim: The aims of this study were: 1) to determine whether the accumulation of aortic root calcification (ARC) assessed using coronary computed tomography angiography (CCTA) can predict future cardiovascular events, and 2) to estimate the onset and progression of ARC in patients with familial hypercholesterolemia (FH). Methods: One hundred thirteen consecutive Japanese patients with heterozygous FH (male = 54, mean age = 52.1 ± 15.6 years, mean LDL-C = 299.0 ± 94.6 mg/dL), without known coronary artery disease, who underwent 64-detector row CCTA were retrospectively evaluated. ARC was defined as the presence of calcium at the aortic root. The extent of ARC was expressed in Agatston units as the ARC-score. Major adverse cardiac events (MACE) were defined as either cardiac death, ST elevated myocardial infarction (STEMI), non-ST elevated myocardial infarction (NSTEMI), unstable angina pectoris (UAP), planned percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG), or stroke. The periods to MACE were estimated using multivariate logistic regression analysis. Results: During the follow-up period (median 1635 days), 19 instances of MACE occurred. Multivariate logistic regression analysis revealed that ARC was a significant independent predictor of MACE (OR= 1.48; 95% CI 1.11–1.87, p < 0.001, respectively). The regression equations were Y= 0.09X − 1.59 (R(2) = 0.34, p < 0.001) in males and Y = 0.08X − 1.60 (R(2) = 0.13, p < 0. 05) in females. Conclusions: ARC was significantly associated with future MACE in Japanese patients with heterozygous FH. ARC may start to develop, on average, at 17.4 and 19.7 years of age in males and females, respectively, with heterozygous FH. Japan Atherosclerosis Society 2018-07-01 /pmc/articles/PMC6055038/ /pubmed/29321389 http://dx.doi.org/10.5551/jat.42705 Text en 2018 Japan Atherosclerosis Society This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Original Article Okada, Hirofumi Tada, Hayato Hayashi, Kenshi Kawashima, Hiroki Takata, Tadanori Sakata, Kenji Nohara, Atsushi Mabuchi, Hiroshi Yamagishi, Masakazu Kawashiri, Masa-aki Aortic Root Calcification Score as an Independent Factor for Predicting Major Adverse Cardiac Events in Familial Hypercholesterolemia |
title | Aortic Root Calcification Score as an Independent Factor for Predicting Major Adverse Cardiac Events in Familial Hypercholesterolemia |
title_full | Aortic Root Calcification Score as an Independent Factor for Predicting Major Adverse Cardiac Events in Familial Hypercholesterolemia |
title_fullStr | Aortic Root Calcification Score as an Independent Factor for Predicting Major Adverse Cardiac Events in Familial Hypercholesterolemia |
title_full_unstemmed | Aortic Root Calcification Score as an Independent Factor for Predicting Major Adverse Cardiac Events in Familial Hypercholesterolemia |
title_short | Aortic Root Calcification Score as an Independent Factor for Predicting Major Adverse Cardiac Events in Familial Hypercholesterolemia |
title_sort | aortic root calcification score as an independent factor for predicting major adverse cardiac events in familial hypercholesterolemia |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055038/ https://www.ncbi.nlm.nih.gov/pubmed/29321389 http://dx.doi.org/10.5551/jat.42705 |
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