Cargando…

Antidiabetic Activity of a Flavonoid-Rich Extract From Sophora davidii (Franch.) Skeels in KK-Ay Mice via Activation of AMP-Activated Protein Kinase

The present study was undertaken to investigate the hypoglycemic activity and potential mechanisms of action of a flavonoid-rich extract from Sophora davidii (Franch.) Skeels (SD-FRE) through in vitro and in vivo studies. Four main flavonoids of SD-FRE namely apigenin, maackiain, leachianone A and l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Yun, Hao, Ji, Tian, Di, Wen, Yanzhang, Zhao, Ping, Chen, Hao, Lv, Yibin, Yang, Xinzhou
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055046/ https://www.ncbi.nlm.nih.gov/pubmed/30061831 http://dx.doi.org/10.3389/fphar.2018.00760

Ejemplares similares

Davidones F and G, Two Novel Flavonoids from Sophora davidii (Franch.) Skeels
por: Song, Ping, et al.
Publicado: (2021)

Chemical Constituents from Roots of Sophora davidii (Franch.) Skeels and Their Glucose Transporter 4 Translocation Activities
por: Li, Kangdi, et al.
Publicado: (2021)

Hypoglycemic Activity and the Potential Mechanism of the Flavonoid Rich Extract from Sophora tonkinensis Gagnep. in KK-Ay Mice
por: Huang, Mi, et al.
Publicado: (2016)

Transcriptomic and Metabolomic Analyses Reveal Key Metabolites, Pathways and Candidate Genes in Sophora davidii (Franch.) Skeels Seedlings Under Drought Stress
por: Zhao, Xin, et al.
Publicado: (2022)

Antioxidant Effects of Sophora davidi (Franch.) Skeels on d–Galactose–Induced Aging Model in Mice via Activating the SIRT1/p53 Pathway
por: Lin, Beibei, et al.
Publicado: (2021)

The complete chloroplast genome of Epimedium davidii Franch. (Berberidaceae)
por: Yang, Qianru, et al.
Publicado: (2020)

The complete chloroplast genome of Pseudostellaria davidii (franch.) Pax, 1934
por: Zhao, Hongye, et al.
Publicado: (2023)

Morphological, transcriptomic and metabolomic analyses of Sophora davidii mutants for plant height
por: Zhao, Xin, et al.
Publicado: (2022)

The complete chloroplast genome of Sophora davidii (Fabaceae) and its phylogenetic implications
por: Sun, Huigai, et al.
Publicado: (2022)

Effect of Bushen Huoxue Prescription on Cognitive Dysfunction of KK-Ay Type 2 Diabetic Mice
por: Zhao, Shao-Yang, et al.
Publicado: (2021)

Nodule-associated diazotrophic community succession is driven by developmental phases combined with microhabitat of Sophora davidii
por: Ai, Jiamin, et al.
Publicado: (2022)

Antidiabetic activity of isoquercetin in diabetic KK -A(y )mice
por: Zhang, Rui, et al.
Publicado: (2011)

Nordic Seaweed and Diabetes Prevention: Exploratory Studies in KK-Ay Mice
por: Sørensen, Lasse E., et al.
Publicado: (2019)

Royal jelly improves hyperglycemia in obese/diabetic KK-Ay mice
por: YOSHIDA, Mei, et al.
Publicado: (2016)

Studies of pathology and pharmacology of diabetic encephalopathy with KK‐Ay mouse model
por: Shi, Si, et al.
Publicado: (2019)

Suramin prevents the development of diabetic kidney disease by inhibiting NLRP3 inflammasome activation in KK‐Ay mice
por: Oda, Kaori, et al.
Publicado: (2022)

Qiwei granules alleviates podocyte lesion in kidney of diabetic KK-Ay mice
por: Zhou, Jingxin, et al.
Publicado: (2015)

Effect of Gamma Rays on Sophora davidii and Detection of DNA Polymorphism through ISSR Marker
por: Wang, Puchang, et al.
Publicado: (2017)

Skin, Liver, and Kidney Interactions Contribute to Skin Dryness in Aging KK-Ay/Tajcl Mice
por: Hiramoto, Keiichi, et al.
Publicado: (2022)

CycloZ Improves Hyperglycemia and Lipid Metabolism by Modulating Lysine Acetylation in KK-Ay Mice
por: Jeon, Jongsu, et al.
Publicado: (2023)

Antioxidant and Anticancer Activities of Wampee (Clausena lansium (Lour.) Skeels) Peel
por: Prasad, K. Nagendra, et al.
Publicado: (2009)

Oxidative Potential and Nanoantioxidant Activity of Flavonoids and Phenolic Acids in Sophora flavescens
por: Zhu, Yujie, et al.
Publicado: (2022)

Antidiabetic Activity of Picris japonica Thunb Aqueous Extract in Diabetic KK-A(y) Mice
por: Jia, Yanmei, et al.
Publicado: (2018)

A Novel Flavonoid Kushenol Z from Sophora flavescens Mediates mTOR Pathway by Inhibiting Phosphodiesterase and Akt Activity to Induce Apoptosis in Non-Small-Cell Lung Cancer Cells
por: Chen, Hao, et al.
Publicado: (2019)

Two New Isoprenoid Flavonoids from Sophora flavescens with Antioxidant and Cytotoxic Activities
por: Li, Jingjing, et al.
Publicado: (2021)

Retracted: Oxidative Potential and Nanoantioxidant Activity of Flavonoids and Phenolic Acids in Sophora flavescens
por: Chemistry, International Journal of Analytical
Publicado: (2023)

Flavonoids from the Roots of Sophora flavescens and Their Potential Anti-Inflammatory and Antiproliferative Activities
por: Yang, Yan-Fei, et al.
Publicado: (2023)

Bone marrow transplantation as a strategy for treatment of non-insulin- dependent diabetes mellitus in KK-Ay mice
Publicado: (1992)

Dementia Is Induced via the AGEs/Iba1/iNOS Pathway in Aged KK-Ay/Tajcl Mice
por: Hiramoto, Keiichi, et al.
Publicado: (2023)

Lessons From the KK-Ay Mouse, a Spontaneous Animal Model for the Treatment of Human Type 2 Diabetic Nephropathy
por: Tomino, Yasuhiko
Publicado: (2012)

Empagliflozin Induces White Adipocyte Browning and Modulates Mitochondrial Dynamics in KK Cg-Ay/J Mice and Mouse Adipocytes
por: Xu, Linxin, et al.
Publicado: (2021)

Changes in the AGE/Macrophage/TNF-α Pathway Affect Skin Dryness during KK-Ay/Tajcl Mice Aging
por: Hiramoto, Keiichi, et al.
Publicado: (2023)

Jiangtang decoction ameliorate diabetic nephropathy through the regulation of PI3K/Akt-mediated NF-κB pathways in KK-Ay mice
por: Hong, Jin-Ni, et al.
Publicado: (2017)

Antidiabetic Effect of Methanolic Extract from Berberis julianae Schneid. via Activation of AMP-Activated Protein Kinase in Type 2 Diabetic Mice
por: Yang, Jing, et al.
Publicado: (2014)

High Insulin Levels in KK-Ay Diabetic Mice Cause Increased Cortical Bone Mass and Impaired Trabecular Micro-Structure
por: Fu, Cen, et al.
Publicado: (2015)

Acetate alters expression of genes involved in beige adipogenesis in 3T3-L1 cells and obese KK-Ay mice
por: Hanatani, Satoko, et al.
Publicado: (2016)

Oral Administration of Lipopolysaccharide Enhances Insulin Signaling-Related Factors in the KK/Ay Mouse Model of Type 2 Diabetes Mellitus
por: Yamamoto, Kazushi, et al.
Publicado: (2023)

Production of Flavonoids in Callus Cultures of Sophora flavescens Aiton
por: Park, Ji-Sun, et al.
Publicado: (2020)

Quantitative determination of total and individual flavonoids in stems and leaves of Buddleja davidii and Buddleja albiflora
por: Ying, Cheng, et al.
Publicado: (2012)

Anti-diabetic effects and mechanisms of action of a Chinese herbal medicine preparation JQ-R in vitro and in diabetic KK(Ay) mice
por: Liu, Quan, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_j7mfq5653p9sghjf5fh25noibt