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Chromatin organization by an interplay of loop extrusion and compartmental segregation
Mammalian chromatin is spatially organized at many scales showing two prominent features in interphase: (i) alternating regions (1–10 Mb) of active and inactive chromatin that spatially segregate into different compartments, and (ii) domains (<1 Mb), that is, regions that preferentially interact...
Autores principales: | Nuebler, Johannes, Fudenberg, Geoffrey, Imakaev, Maxim, Abdennur, Nezar, Mirny, Leonid A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055145/ https://www.ncbi.nlm.nih.gov/pubmed/29967174 http://dx.doi.org/10.1073/pnas.1717730115 |
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