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Interleukin-6 trans-signaling contributes to chronic hypoxia-induced pulmonary hypertension

Interleukin-6 (IL-6) is a pleotropic cytokine that signals through the membrane-bound IL-6 receptor (mIL-6R) to induce anti-inflammatory (“classic-signaling”) responses. This cytokine also binds to the soluble IL-6R (sIL-6R) to promote inflammation (“trans-signaling”). mIL-6R expression is restricte...

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Detalles Bibliográficos
Autores principales:	Maston, Levi D., Jones, David T., Giermakowska, Wieslawa, Resta, Thomas C., Ramiro-Diaz, Juan, Howard, Tamara A., Jernigan, Nikki L., Herbert, Lindsay, Maurice, Anna A., Gonzalez Bosc, Laura V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055240/ https://www.ncbi.nlm.nih.gov/pubmed/29767573 http://dx.doi.org/10.1177/2045894018780734

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