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Glucose-sensing microRNA-21 disrupts ROS homeostasis and impairs antioxidant responses in cellular glucose variability

BACKGROUND: Antioxidant enzymes play a fundamental role in counteracting oxidative stress induced by high glucose. Although mitochondrial superoxide dismutase (SOD2) is the principal defence against the toxicity of superoxide anions, the mechanism of its inactivation in diabetic subjects is still po...

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Detalles Bibliográficos
Autores principales:	La Sala, Lucia, Mrakic-Sposta, Simona, Micheloni, Stefano, Prattichizzo, Francesco, Ceriello, Antonio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055345/ https://www.ncbi.nlm.nih.gov/pubmed/30037352 http://dx.doi.org/10.1186/s12933-018-0748-2

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