Cargando…
DNA polymerase ζ deficiency causes impaired wound healing and stress-induced skin pigmentation
DNA polymerase ζ (pol ζ) is well established as a specialized enzyme important for DNA damage tolerance, facilitating DNA synthesis past lesions caused by radiation or chemical damage. We report that disruption of Rev3l (encoding the catalytic subunit of pol ζ) in mouse epidermis leads to a defect i...
Autores principales: | Lange, Sabine S, Bhetawal, Sarita, Reh, Shelley, Powell, Katherine Leslie, Kusewitt, Donna F, Wood, Richard D |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Life Science Alliance LLC
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055517/ https://www.ncbi.nlm.nih.gov/pubmed/30046772 http://dx.doi.org/10.26508/lsa.201800048 |
Ejemplares similares
-
The Polymerase Activity of Mammalian DNA Pol ζ Is Specifically Required for Cell and Embryonic Viability
por: Lange, Sabine S., et al.
Publicado: (2016) -
REV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase ζ
por: Tomida, Junya, et al.
Publicado: (2015) -
Analysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance
por: Takata, Kei-ichi, et al.
Publicado: (2017) -
DNA polymerase ζ in DNA replication and repair
por: Martin, Sara K, et al.
Publicado: (2019) -
Pigmented skin exhibits accelerated wound healing compared to the nonpigmented skin in Guinea pig model
por: Gupta, Rohit, et al.
Publicado: (2023)