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Clinical associations between allergies and rapid eye movement sleep disturbances

BACKGROUND: Allergic rhinitis, an immunoglobulin E inflammatory condition including nasal congestion, obstruction, sneezing, pruritus, and fatigue symptoms, has significant impact on quality of life and impairs sleep. Sleep‐disordered breathing (SDB) patients often have normal all‐night apnea‐hypopn...

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Autores principales: Berson, Shelley R., Klimczak, Jaclyn, Prezio, Elizabeth A., Hu, Shirley, Abraham, Manoj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055599/
https://www.ncbi.nlm.nih.gov/pubmed/29461689
http://dx.doi.org/10.1002/alr.22099
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author Berson, Shelley R.
Klimczak, Jaclyn
Prezio, Elizabeth A.
Hu, Shirley
Abraham, Manoj
author_facet Berson, Shelley R.
Klimczak, Jaclyn
Prezio, Elizabeth A.
Hu, Shirley
Abraham, Manoj
author_sort Berson, Shelley R.
collection PubMed
description BACKGROUND: Allergic rhinitis, an immunoglobulin E inflammatory condition including nasal congestion, obstruction, sneezing, pruritus, and fatigue symptoms, has significant impact on quality of life and impairs sleep. Sleep‐disordered breathing (SDB) patients often have normal all‐night apnea‐hypopnea (AHI) or respiratory‐disturbance (RDI) indices on polysomnography (PSG). We hypothesized that the rapid eye motion–respiratory disturbance index (REM‐RDI) may be a novel predictor of allergic status. METHODS: A retrospective analysis of 100 patients compared REM‐RDI results in 67 allergen‐positive patients with 33 nonallergic patients who presented with nasal blockage. Subjects completed STOP‐Bang©, 22‐item Sino‐Nasal Outcome Test (SNOT‐22)©, and Epworth Sleepiness Scale© questionnaires and underwent skin‐prick testing (SPT) and PSGs including REM‐RDI values. Using multivariate logistic regression models, we evaluated relationships between allergic status and sleep parameters while controlling for possible confounders including body mass index (BMI). RESULTS: Using REM‐RDI as the outcome of interest, allergen‐positive patients were 3.92 times more likely to have REM‐RDI values in a moderate/severe range (≥15 events/hour); and patients with moderate/severe REM‐RDI values were more likely to be allergen positive (p < 0.05). Allergic status was not significantly related to all‐night AHI, RDI, or REM‐AHI. BMI was not significantly related to REM‐RDI. STOP‐Bang© was related to allergy status (p = 0.02) and REM‐RDI (p < 0.01). Allergic patients had increased REM latency and less total amount of REM. CONCLUSION: We revealed significant bidirectional associations between allergen positivity and increased REM‐RDI values independent of BMI, AHI, RDI, and REM‐AHI. Allergic inflammation and REM‐RDI data may play important roles in diagnosing and treating fatigued SDB patients and as objective perioperative safety and outcomes measures.
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spelling pubmed-60555992018-07-23 Clinical associations between allergies and rapid eye movement sleep disturbances Berson, Shelley R. Klimczak, Jaclyn Prezio, Elizabeth A. Hu, Shirley Abraham, Manoj Int Forum Allergy Rhinol Original Articles BACKGROUND: Allergic rhinitis, an immunoglobulin E inflammatory condition including nasal congestion, obstruction, sneezing, pruritus, and fatigue symptoms, has significant impact on quality of life and impairs sleep. Sleep‐disordered breathing (SDB) patients often have normal all‐night apnea‐hypopnea (AHI) or respiratory‐disturbance (RDI) indices on polysomnography (PSG). We hypothesized that the rapid eye motion–respiratory disturbance index (REM‐RDI) may be a novel predictor of allergic status. METHODS: A retrospective analysis of 100 patients compared REM‐RDI results in 67 allergen‐positive patients with 33 nonallergic patients who presented with nasal blockage. Subjects completed STOP‐Bang©, 22‐item Sino‐Nasal Outcome Test (SNOT‐22)©, and Epworth Sleepiness Scale© questionnaires and underwent skin‐prick testing (SPT) and PSGs including REM‐RDI values. Using multivariate logistic regression models, we evaluated relationships between allergic status and sleep parameters while controlling for possible confounders including body mass index (BMI). RESULTS: Using REM‐RDI as the outcome of interest, allergen‐positive patients were 3.92 times more likely to have REM‐RDI values in a moderate/severe range (≥15 events/hour); and patients with moderate/severe REM‐RDI values were more likely to be allergen positive (p < 0.05). Allergic status was not significantly related to all‐night AHI, RDI, or REM‐AHI. BMI was not significantly related to REM‐RDI. STOP‐Bang© was related to allergy status (p = 0.02) and REM‐RDI (p < 0.01). Allergic patients had increased REM latency and less total amount of REM. CONCLUSION: We revealed significant bidirectional associations between allergen positivity and increased REM‐RDI values independent of BMI, AHI, RDI, and REM‐AHI. Allergic inflammation and REM‐RDI data may play important roles in diagnosing and treating fatigued SDB patients and as objective perioperative safety and outcomes measures. John Wiley and Sons Inc. 2018-02-20 2018-07 /pmc/articles/PMC6055599/ /pubmed/29461689 http://dx.doi.org/10.1002/alr.22099 Text en © 2018 The Authors International Forum of Allergy & Rhinology, published by ARSAAOA, LLC This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Berson, Shelley R.
Klimczak, Jaclyn
Prezio, Elizabeth A.
Hu, Shirley
Abraham, Manoj
Clinical associations between allergies and rapid eye movement sleep disturbances
title Clinical associations between allergies and rapid eye movement sleep disturbances
title_full Clinical associations between allergies and rapid eye movement sleep disturbances
title_fullStr Clinical associations between allergies and rapid eye movement sleep disturbances
title_full_unstemmed Clinical associations between allergies and rapid eye movement sleep disturbances
title_short Clinical associations between allergies and rapid eye movement sleep disturbances
title_sort clinical associations between allergies and rapid eye movement sleep disturbances
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055599/
https://www.ncbi.nlm.nih.gov/pubmed/29461689
http://dx.doi.org/10.1002/alr.22099
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