Rapid Aqueous Late‐Stage Radiolabelling of [GaF(3)(BnMe(2)‐tacn)] by (18)F/(19)F Isotopic Exchange: Towards New PET Imaging Probes

A simple and rapid method for (18)F radiolabelling of [GaF(3)(BnMe(2)‐tacn)] by (18)F/(19)F isotopic exchange is described. The use of MeCN/H(2)O or EtOH/H(2)O (75:25) and aqueous [(18)F]F(−) (up to 200 MBq) with heating (80 °C, 10 min) gave 66±4 % (18)F incorporation at a concentration of 268 nm, a...

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Autores principales: Monzittu, Francesco M., Khan, Imtiaz, Levason, William, Luthra, Sajinder K., McRobbie, Graeme, Reid, Gillian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055623/
https://www.ncbi.nlm.nih.gov/pubmed/29659110
http://dx.doi.org/10.1002/anie.201802446
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author Monzittu, Francesco M.
Khan, Imtiaz
Levason, William
Luthra, Sajinder K.
McRobbie, Graeme
Reid, Gillian
author_facet Monzittu, Francesco M.
Khan, Imtiaz
Levason, William
Luthra, Sajinder K.
McRobbie, Graeme
Reid, Gillian
author_sort Monzittu, Francesco M.
collection PubMed
description A simple and rapid method for (18)F radiolabelling of [GaF(3)(BnMe(2)‐tacn)] by (18)F/(19)F isotopic exchange is described. The use of MeCN/H(2)O or EtOH/H(2)O (75:25) and aqueous [(18)F]F(−) (up to 200 MBq) with heating (80 °C, 10 min) gave 66±4 % (18)F incorporation at a concentration of 268 nm, and 37±5 % (18)F incorporation at even lower concentration (27 nm), without the need for a Lewis acid promoter. A solid‐phase extraction method was established to give [Ga(18)F(19)F(2)(BnMe(2)‐tacn)] in 99 % radiochemical purity in an EtOH/H(2)O mixture.
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spelling pubmed-60556232018-07-23 Rapid Aqueous Late‐Stage Radiolabelling of [GaF(3)(BnMe(2)‐tacn)] by (18)F/(19)F Isotopic Exchange: Towards New PET Imaging Probes Monzittu, Francesco M. Khan, Imtiaz Levason, William Luthra, Sajinder K. McRobbie, Graeme Reid, Gillian Angew Chem Int Ed Engl Communications A simple and rapid method for (18)F radiolabelling of [GaF(3)(BnMe(2)‐tacn)] by (18)F/(19)F isotopic exchange is described. The use of MeCN/H(2)O or EtOH/H(2)O (75:25) and aqueous [(18)F]F(−) (up to 200 MBq) with heating (80 °C, 10 min) gave 66±4 % (18)F incorporation at a concentration of 268 nm, and 37±5 % (18)F incorporation at even lower concentration (27 nm), without the need for a Lewis acid promoter. A solid‐phase extraction method was established to give [Ga(18)F(19)F(2)(BnMe(2)‐tacn)] in 99 % radiochemical purity in an EtOH/H(2)O mixture. John Wiley and Sons Inc. 2018-04-26 2018-05-28 /pmc/articles/PMC6055623/ /pubmed/29659110 http://dx.doi.org/10.1002/anie.201802446 Text en © 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Monzittu, Francesco M.
Khan, Imtiaz
Levason, William
Luthra, Sajinder K.
McRobbie, Graeme
Reid, Gillian
Rapid Aqueous Late‐Stage Radiolabelling of [GaF(3)(BnMe(2)‐tacn)] by (18)F/(19)F Isotopic Exchange: Towards New PET Imaging Probes
title Rapid Aqueous Late‐Stage Radiolabelling of [GaF(3)(BnMe(2)‐tacn)] by (18)F/(19)F Isotopic Exchange: Towards New PET Imaging Probes
title_full Rapid Aqueous Late‐Stage Radiolabelling of [GaF(3)(BnMe(2)‐tacn)] by (18)F/(19)F Isotopic Exchange: Towards New PET Imaging Probes
title_fullStr Rapid Aqueous Late‐Stage Radiolabelling of [GaF(3)(BnMe(2)‐tacn)] by (18)F/(19)F Isotopic Exchange: Towards New PET Imaging Probes
title_full_unstemmed Rapid Aqueous Late‐Stage Radiolabelling of [GaF(3)(BnMe(2)‐tacn)] by (18)F/(19)F Isotopic Exchange: Towards New PET Imaging Probes
title_short Rapid Aqueous Late‐Stage Radiolabelling of [GaF(3)(BnMe(2)‐tacn)] by (18)F/(19)F Isotopic Exchange: Towards New PET Imaging Probes
title_sort rapid aqueous late‐stage radiolabelling of [gaf(3)(bnme(2)‐tacn)] by (18)f/(19)f isotopic exchange: towards new pet imaging probes
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055623/
https://www.ncbi.nlm.nih.gov/pubmed/29659110
http://dx.doi.org/10.1002/anie.201802446
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