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In silico-guided sequence modifications of K-ras epitopes improve immunological outcome against G12V and G13D mutant KRAS antigens

BACKGROUND: Somatic point substitution mutations in the KRAS proto-oncogene primarily affect codons 12/13 where glycine is converted into other amino acids, and are highly prevalent in pancreatic, colorectal, and non-small cell lung cancers. These cohorts are non-responsive to anti-EGFR treatments,...

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Detalles Bibliográficos
Autores principales:	Ng, Allan Wee Ren, Tan, Pei Jun, Hoo, Winfrey Pui Yee, Liew, Dek Shen, Teo, Michelle Yee Mun, Siak, Pui Yan, Ng, Sze Man, Tan, Ee Wern, Abdul Rahim, Raha, Lim, Renee Lay Hong, Song, Adelene Ai Lian, In, Lionel Lian Aun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2018
Materias:	Bioinformatics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055689/ https://www.ncbi.nlm.nih.gov/pubmed/30042874 http://dx.doi.org/10.7717/peerj.5056

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