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Virtual Fragment Screening Identification of a Quinoline‐5,8‐dicarboxylic Acid Derivative as a Selective JMJD3 Inhibitor

The quinoline‐5,8 dicarboxylic acid scaffold has been identified by a fragment‐based approach as new potential lead compound for the development of JMJD3 inhibitors. Among them, 3‐(2,4‐dimethoxypyrimidin‐5‐yl)quinoline‐5,8‐dicarboxylic acid (compound 3) shows low micromolar inhibitory activity again...

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Detalles Bibliográficos
Autores principales:	Giordano, Assunta, del Gaudio, Federica, Johansson, Catrine, Riccio, Raffaele, Oppermann, Udo, Di Micco, Simone
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055880/ https://www.ncbi.nlm.nih.gov/pubmed/29633584 http://dx.doi.org/10.1002/cmdc.201800198

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