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Entrectinib: an orally available, selective tyrosine kinase inhibitor for the treatment of NTRK, ROS1, and ALK fusion-positive solid tumors

Entrectinib is a potent small-molecule tyrosine kinase inhibitor that targets oncogenic rearrangements in NTRK, ROS1, and ALK. The consolidated results of 2 Phase I trials demonstrated activity in tyrosine kinase inhibitor-naïve patients along with substantial intracranial activity. In ROS1-rearrang...

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Detalles Bibliográficos
Autores principales:	Liu, Dazhi, Offin, Michael, Harnicar, Stephen, Li, Bob T, Drilon, Alexander
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055893/ https://www.ncbi.nlm.nih.gov/pubmed/30050303 http://dx.doi.org/10.2147/TCRM.S147381

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