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Preoperative circulating FPR and CCF score are promising biomarkers for predicting clinical outcome of stage II–III colorectal cancer patients

INTRODUCTION: Inflammation and nutrition are considered as two important causes leading to the progression and poor survival of colorectal cancer (CRC). The objective of this study is to investigate the prognostic significance of preoperative albumin-to-fibrinogen ratio (AFR), fibrinogen-to-pre-albu...

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Autores principales: Sun, Fan, Peng, Hong-Xin, Gao, Qiu-Fang, Li, Shu-Qi, Zhang, Jing, Chen, Qing-Gen, Jiang, Yu-Huan, Zhang, Lei, Wang, Xiao-Zhong, Ying, Hou-Qun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055907/
https://www.ncbi.nlm.nih.gov/pubmed/30050325
http://dx.doi.org/10.2147/CMAR.S167398
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author Sun, Fan
Peng, Hong-Xin
Gao, Qiu-Fang
Li, Shu-Qi
Zhang, Jing
Chen, Qing-Gen
Jiang, Yu-Huan
Zhang, Lei
Wang, Xiao-Zhong
Ying, Hou-Qun
author_facet Sun, Fan
Peng, Hong-Xin
Gao, Qiu-Fang
Li, Shu-Qi
Zhang, Jing
Chen, Qing-Gen
Jiang, Yu-Huan
Zhang, Lei
Wang, Xiao-Zhong
Ying, Hou-Qun
author_sort Sun, Fan
collection PubMed
description INTRODUCTION: Inflammation and nutrition are considered as two important causes leading to the progression and poor survival of colorectal cancer (CRC). The objective of this study is to investigate the prognostic significance of preoperative albumin-to-fibrinogen ratio (AFR), fibrinogen-to-pre-albumin ratio (FPR), fibrinogen (Fib), albumin (Alb), and pre-albumin (pre-Alb) in CRC individuals. MATERIALS AND METHODS: In this study, 3 years’ follow-up was carried out in 702 stage I–III resected CRC patients diagnosed between January 2008 and December 2013. The optimal cutoff points and prognostic values of AFR, FPR, Fib, Alb, pre-Alb, and a novel carcinoembryonic antigen (CEA)-carbohydrate antigen 19-9 (CA199)-FPR (CCF) score were assessed by X-tile software, Kaplan–Meier curve, and Cox regression model. We established the CRC prognostic nomogram, and its predictive efficacy was determined by Harrell’s concordance index (c-index). RESULTS: Our results showed that high FPR was obviously correlated with poor survival of CRC patients. The prognostic predictive efficacy of CCF score was superior to FPR, CEA, CA199, CEA-CA199 (CCI), and CEA-FPR (CFI) score. Moreover, stage II–III patients harboring high FPR or elevated CCF (score≥1) could benefit from adjuvant chemotherapy, rather than those with low FPR or CCF (score=0). Additionally, the c-index (0.728) of the nomogram containing CCF score was significantly higher than that (0.626) without it (p<0.01). CONCLUSION: These findings illustrated that FPR and CCF score were promising biomarkers to predict the prognosis of CRC and to classify the stage II–III patients who could benefit from the adjuvant chemotherapy.
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spelling pubmed-60559072018-07-26 Preoperative circulating FPR and CCF score are promising biomarkers for predicting clinical outcome of stage II–III colorectal cancer patients Sun, Fan Peng, Hong-Xin Gao, Qiu-Fang Li, Shu-Qi Zhang, Jing Chen, Qing-Gen Jiang, Yu-Huan Zhang, Lei Wang, Xiao-Zhong Ying, Hou-Qun Cancer Manag Res Original Research INTRODUCTION: Inflammation and nutrition are considered as two important causes leading to the progression and poor survival of colorectal cancer (CRC). The objective of this study is to investigate the prognostic significance of preoperative albumin-to-fibrinogen ratio (AFR), fibrinogen-to-pre-albumin ratio (FPR), fibrinogen (Fib), albumin (Alb), and pre-albumin (pre-Alb) in CRC individuals. MATERIALS AND METHODS: In this study, 3 years’ follow-up was carried out in 702 stage I–III resected CRC patients diagnosed between January 2008 and December 2013. The optimal cutoff points and prognostic values of AFR, FPR, Fib, Alb, pre-Alb, and a novel carcinoembryonic antigen (CEA)-carbohydrate antigen 19-9 (CA199)-FPR (CCF) score were assessed by X-tile software, Kaplan–Meier curve, and Cox regression model. We established the CRC prognostic nomogram, and its predictive efficacy was determined by Harrell’s concordance index (c-index). RESULTS: Our results showed that high FPR was obviously correlated with poor survival of CRC patients. The prognostic predictive efficacy of CCF score was superior to FPR, CEA, CA199, CEA-CA199 (CCI), and CEA-FPR (CFI) score. Moreover, stage II–III patients harboring high FPR or elevated CCF (score≥1) could benefit from adjuvant chemotherapy, rather than those with low FPR or CCF (score=0). Additionally, the c-index (0.728) of the nomogram containing CCF score was significantly higher than that (0.626) without it (p<0.01). CONCLUSION: These findings illustrated that FPR and CCF score were promising biomarkers to predict the prognosis of CRC and to classify the stage II–III patients who could benefit from the adjuvant chemotherapy. Dove Medical Press 2018-07-19 /pmc/articles/PMC6055907/ /pubmed/30050325 http://dx.doi.org/10.2147/CMAR.S167398 Text en © 2018 Sun et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Sun, Fan
Peng, Hong-Xin
Gao, Qiu-Fang
Li, Shu-Qi
Zhang, Jing
Chen, Qing-Gen
Jiang, Yu-Huan
Zhang, Lei
Wang, Xiao-Zhong
Ying, Hou-Qun
Preoperative circulating FPR and CCF score are promising biomarkers for predicting clinical outcome of stage II–III colorectal cancer patients
title Preoperative circulating FPR and CCF score are promising biomarkers for predicting clinical outcome of stage II–III colorectal cancer patients
title_full Preoperative circulating FPR and CCF score are promising biomarkers for predicting clinical outcome of stage II–III colorectal cancer patients
title_fullStr Preoperative circulating FPR and CCF score are promising biomarkers for predicting clinical outcome of stage II–III colorectal cancer patients
title_full_unstemmed Preoperative circulating FPR and CCF score are promising biomarkers for predicting clinical outcome of stage II–III colorectal cancer patients
title_short Preoperative circulating FPR and CCF score are promising biomarkers for predicting clinical outcome of stage II–III colorectal cancer patients
title_sort preoperative circulating fpr and ccf score are promising biomarkers for predicting clinical outcome of stage ii–iii colorectal cancer patients
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055907/
https://www.ncbi.nlm.nih.gov/pubmed/30050325
http://dx.doi.org/10.2147/CMAR.S167398
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