PGL I expression in live bacteria allows activation of a CD206/PPARγ cross-talk that may contribute to successful Mycobacterium leprae colonization of peripheral nerves

Mycobacterium leprae, an obligate intracellular bacillus, infects Schwann cells (SCs), leading to peripheral nerve damage, the most severe leprosy symptom. In the present study, we revisited the involvement of phenolic glycolipid I (PGL I), an abundant, private, surface M. leprae molecule, in M. lep...

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Detalles Bibliográficos
Autores principales: Díaz Acosta, Chyntia Carolina, Dias, André Alves, Rosa, Thabatta Leal Silveira Andrezo, Batista-Silva, Leonardo Ribeiro, Rosa, Patricia Sammarco, Toledo-Pinto, Thiago Gomes, Costa, Fabrício da Mota Ramalho, Lara, Flávio Alves, Rodrigues, Luciana Silva, Mattos, Katherine Antunes, Sarno, Euzenir Nunes, Bozza, Patrícia Torres, Guilhot, Christophe, de Berrêdo-Pinho, Márcia, Pessolani, Maria Cristina Vidal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056075/
https://www.ncbi.nlm.nih.gov/pubmed/29979790
http://dx.doi.org/10.1371/journal.ppat.1007151

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