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Clonal Expansion of Macrolide-Resistant Sequence Type 3 Mycoplasma pneumoniae, South Korea

To investigate the genetic background for the emergence of macrolide resistance, we characterized the genetic features of Mycoplasma pneumoniae using multilocus sequence typing. Of the 146 M. pneumoniae strains collected during the 5 consecutive outbreaks of M. pneumoniae pneumonia during 2000–2016...

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Autores principales: Lee, Joon Kee, Lee, Joon Ho, Lee, Hyunju, Ahn, Young Min, Eun, Byung Wook, Cho, Eun Young, Cho, Hwa Jin, Yun, Ki Wook, Lee, Hoan Jong, Choi, Eun Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056092/
https://www.ncbi.nlm.nih.gov/pubmed/30014844
http://dx.doi.org/10.3201/eid2408.180081
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author Lee, Joon Kee
Lee, Joon Ho
Lee, Hyunju
Ahn, Young Min
Eun, Byung Wook
Cho, Eun Young
Cho, Hwa Jin
Yun, Ki Wook
Lee, Hoan Jong
Choi, Eun Hwa
author_facet Lee, Joon Kee
Lee, Joon Ho
Lee, Hyunju
Ahn, Young Min
Eun, Byung Wook
Cho, Eun Young
Cho, Hwa Jin
Yun, Ki Wook
Lee, Hoan Jong
Choi, Eun Hwa
author_sort Lee, Joon Kee
collection PubMed
description To investigate the genetic background for the emergence of macrolide resistance, we characterized the genetic features of Mycoplasma pneumoniae using multilocus sequence typing. Of the 146 M. pneumoniae strains collected during the 5 consecutive outbreaks of M. pneumoniae pneumonia during 2000–2016 in South Korea, macrolide resistance increased from 0% in the first outbreak to 84.4% in the fifth. Among the 8 sequence types (STs) identified, ST3 (74.7%) was the most prevalent, followed by ST14 (15.1%). Macrolide-susceptible strains comprised 8 different STs, and all macrolide-resistant strains were ST3 (98.3%) except 1 with ST14. The proportion of macrolide-resistant strains in ST3 remained 2.2% (1/46) until the 2006–2007 outbreak and then markedly increased to 82.6% (19/23) during the 2010–2012 outbreak and 95.0% (38/40) during the 2014–2016 outbreak. The findings demonstrated that clonal expansion of ST3 M. pneumoniae was associated with the increase in macrolide resistance in South Korea.
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spelling pubmed-60560922018-08-01 Clonal Expansion of Macrolide-Resistant Sequence Type 3 Mycoplasma pneumoniae, South Korea Lee, Joon Kee Lee, Joon Ho Lee, Hyunju Ahn, Young Min Eun, Byung Wook Cho, Eun Young Cho, Hwa Jin Yun, Ki Wook Lee, Hoan Jong Choi, Eun Hwa Emerg Infect Dis Research To investigate the genetic background for the emergence of macrolide resistance, we characterized the genetic features of Mycoplasma pneumoniae using multilocus sequence typing. Of the 146 M. pneumoniae strains collected during the 5 consecutive outbreaks of M. pneumoniae pneumonia during 2000–2016 in South Korea, macrolide resistance increased from 0% in the first outbreak to 84.4% in the fifth. Among the 8 sequence types (STs) identified, ST3 (74.7%) was the most prevalent, followed by ST14 (15.1%). Macrolide-susceptible strains comprised 8 different STs, and all macrolide-resistant strains were ST3 (98.3%) except 1 with ST14. The proportion of macrolide-resistant strains in ST3 remained 2.2% (1/46) until the 2006–2007 outbreak and then markedly increased to 82.6% (19/23) during the 2010–2012 outbreak and 95.0% (38/40) during the 2014–2016 outbreak. The findings demonstrated that clonal expansion of ST3 M. pneumoniae was associated with the increase in macrolide resistance in South Korea. Centers for Disease Control and Prevention 2018-08 /pmc/articles/PMC6056092/ /pubmed/30014844 http://dx.doi.org/10.3201/eid2408.180081 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Lee, Joon Kee
Lee, Joon Ho
Lee, Hyunju
Ahn, Young Min
Eun, Byung Wook
Cho, Eun Young
Cho, Hwa Jin
Yun, Ki Wook
Lee, Hoan Jong
Choi, Eun Hwa
Clonal Expansion of Macrolide-Resistant Sequence Type 3 Mycoplasma pneumoniae, South Korea
title Clonal Expansion of Macrolide-Resistant Sequence Type 3 Mycoplasma pneumoniae, South Korea
title_full Clonal Expansion of Macrolide-Resistant Sequence Type 3 Mycoplasma pneumoniae, South Korea
title_fullStr Clonal Expansion of Macrolide-Resistant Sequence Type 3 Mycoplasma pneumoniae, South Korea
title_full_unstemmed Clonal Expansion of Macrolide-Resistant Sequence Type 3 Mycoplasma pneumoniae, South Korea
title_short Clonal Expansion of Macrolide-Resistant Sequence Type 3 Mycoplasma pneumoniae, South Korea
title_sort clonal expansion of macrolide-resistant sequence type 3 mycoplasma pneumoniae, south korea
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056092/
https://www.ncbi.nlm.nih.gov/pubmed/30014844
http://dx.doi.org/10.3201/eid2408.180081
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