Plasmodium falciparum Plasmepsin 2 Duplications, West Africa

Dihydroartemisinin/piperaquine (DHA/PPQ) is increasingly deployed as an antimalaria drug in Africa. We report the detection in Mali of Plasmodium falciparum infections carrying plasmepsin 2 duplications (associated with piperaquine resistance) in 7/65 recurrent infections within 2 months after DHA/P...

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Detalles Bibliográficos
Autores principales: Inoue, Juliana, Silva, Miguel, Fofana, Bakary, Sanogo, Kassim, Mårtensson, Andreas, Sagara, Issaka, Björkman, Anders, Veiga, Maria Isabel, Ferreira, Pedro Eduardo, Djimde, Abdoulaye, Gil, José Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2018
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056108/
https://www.ncbi.nlm.nih.gov/pubmed/29798744
http://dx.doi.org/10.3201/eid2408.180370
Descripción
Sumario:Dihydroartemisinin/piperaquine (DHA/PPQ) is increasingly deployed as an antimalaria drug in Africa. We report the detection in Mali of Plasmodium falciparum infections carrying plasmepsin 2 duplications (associated with piperaquine resistance) in 7/65 recurrent infections within 2 months after DHA/PPQ treatment. These findings raise concerns about the long-term efficacy of DHA/PPQ treatment in Africa.

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