Plasmodium falciparum Plasmepsin 2 Duplications, West Africa

Dihydroartemisinin/piperaquine (DHA/PPQ) is increasingly deployed as an antimalaria drug in Africa. We report the detection in Mali of Plasmodium falciparum infections carrying plasmepsin 2 duplications (associated with piperaquine resistance) in 7/65 recurrent infections within 2 months after DHA/P...

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Detalles Bibliográficos
Autores principales: Inoue, Juliana, Silva, Miguel, Fofana, Bakary, Sanogo, Kassim, Mårtensson, Andreas, Sagara, Issaka, Björkman, Anders, Veiga, Maria Isabel, Ferreira, Pedro Eduardo, Djimde, Abdoulaye, Gil, José Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2018
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056108/
https://www.ncbi.nlm.nih.gov/pubmed/29798744
http://dx.doi.org/10.3201/eid2408.180370
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author Inoue, Juliana
Silva, Miguel
Fofana, Bakary
Sanogo, Kassim
Mårtensson, Andreas
Sagara, Issaka
Björkman, Anders
Veiga, Maria Isabel
Ferreira, Pedro Eduardo
Djimde, Abdoulaye
Gil, José Pedro
author_facet Inoue, Juliana
Silva, Miguel
Fofana, Bakary
Sanogo, Kassim
Mårtensson, Andreas
Sagara, Issaka
Björkman, Anders
Veiga, Maria Isabel
Ferreira, Pedro Eduardo
Djimde, Abdoulaye
Gil, José Pedro
author_sort Inoue, Juliana
collection PubMed
description Dihydroartemisinin/piperaquine (DHA/PPQ) is increasingly deployed as an antimalaria drug in Africa. We report the detection in Mali of Plasmodium falciparum infections carrying plasmepsin 2 duplications (associated with piperaquine resistance) in 7/65 recurrent infections within 2 months after DHA/PPQ treatment. These findings raise concerns about the long-term efficacy of DHA/PPQ treatment in Africa.
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spelling pubmed-60561082018-08-01 Plasmodium falciparum Plasmepsin 2 Duplications, West Africa Inoue, Juliana Silva, Miguel Fofana, Bakary Sanogo, Kassim Mårtensson, Andreas Sagara, Issaka Björkman, Anders Veiga, Maria Isabel Ferreira, Pedro Eduardo Djimde, Abdoulaye Gil, José Pedro Emerg Infect Dis Research Letter Dihydroartemisinin/piperaquine (DHA/PPQ) is increasingly deployed as an antimalaria drug in Africa. We report the detection in Mali of Plasmodium falciparum infections carrying plasmepsin 2 duplications (associated with piperaquine resistance) in 7/65 recurrent infections within 2 months after DHA/PPQ treatment. These findings raise concerns about the long-term efficacy of DHA/PPQ treatment in Africa. Centers for Disease Control and Prevention 2018-08 /pmc/articles/PMC6056108/ /pubmed/29798744 http://dx.doi.org/10.3201/eid2408.180370 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Inoue, Juliana
Silva, Miguel
Fofana, Bakary
Sanogo, Kassim
Mårtensson, Andreas
Sagara, Issaka
Björkman, Anders
Veiga, Maria Isabel
Ferreira, Pedro Eduardo
Djimde, Abdoulaye
Gil, José Pedro
Plasmodium falciparum Plasmepsin 2 Duplications, West Africa
title Plasmodium falciparum Plasmepsin 2 Duplications, West Africa
title_full Plasmodium falciparum Plasmepsin 2 Duplications, West Africa
title_fullStr Plasmodium falciparum Plasmepsin 2 Duplications, West Africa
title_full_unstemmed Plasmodium falciparum Plasmepsin 2 Duplications, West Africa
title_short Plasmodium falciparum Plasmepsin 2 Duplications, West Africa
title_sort plasmodium falciparum plasmepsin 2 duplications, west africa
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056108/
https://www.ncbi.nlm.nih.gov/pubmed/29798744
http://dx.doi.org/10.3201/eid2408.180370
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