Fatal Nongroupable Neisseria meningitidis Disease in Vaccinated Patient Receiving Eculizumab

Patients receiving eculizumab have an increased risk for meningococcal disease, but most reported cases are attributable to encapsulated meningococcal strains. We describe a case in which a nongroupable meningococcal strain, which rarely causes disease in healthy persons, caused fatal disease in an...

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Detalles Bibliográficos
Autores principales: Nolfi-Donegan, Deirdre, Konar, Monica, Vianzon, Vianca, MacNeil, Jessica, Cooper, James, Lurie, Perrianne, Sedivy, Judi, Wang, Xin, Granoff, Dan M., McNamara, Lucy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2018
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056112/
https://www.ncbi.nlm.nih.gov/pubmed/30015608
http://dx.doi.org/10.3201/eid2408.180228
Descripción
Sumario:Patients receiving eculizumab have an increased risk for meningococcal disease, but most reported cases are attributable to encapsulated meningococcal strains. We describe a case in which a nongroupable meningococcal strain, which rarely causes disease in healthy persons, caused fatal disease in an eculizumab recipient despite meningococcal vaccination.

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