Case Definition of Chronic Pulmonary Aspergillosis in Resource-Constrained Settings

Chronic pulmonary aspergillosis (CPA) is a recognized complication of pulmonary tuberculosis (TB). In 2015, the World Health Organization reported 2.2 million new cases of nonbacteriologically confirmed pulmonary TB; some of these patients probably had undiagnosed CPA. In October 2016, the Global Ac...

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Detalles Bibliográficos
Autores principales: Denning, David W., Page, Iain D., Chakaya, Jeremiah, Jabeen, Kauser, Jude, Cecilia M., Cornet, Muriel, Alastruey-Izquierdo, Ana, Bongomin, Felix, Bowyer, Paul, Chakrabarti, Arunaloke, Gago, Sara, Guto, John, Hochhegger, Bruno, Hoenigl, Martin, Irfan, Muhammad, Irurhe, Nicholas, Izumikawa, Koichi, Kirenga, Bruce, Manduku, Veronica, Moazam, Samihah, Oladele, Rita O., Richardson, Malcolm D., Tudela, Juan Luis Rodriguez, Rozaliyani, Anna, Salzer, Helmut J.F., Sawyer, Richard, Simukulwa, Nasilele F., Skrahina, Alena, Sriruttan, Charlotte, Setianingrum, Findra, Wilopo, Bayu A.P., Cole, Donald C., Getahun, Haileyesus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2018
Materias:
Online Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056117/
https://www.ncbi.nlm.nih.gov/pubmed/30016256
http://dx.doi.org/10.3201/eid2408.171312
Descripción
Sumario:Chronic pulmonary aspergillosis (CPA) is a recognized complication of pulmonary tuberculosis (TB). In 2015, the World Health Organization reported 2.2 million new cases of nonbacteriologically confirmed pulmonary TB; some of these patients probably had undiagnosed CPA. In October 2016, the Global Action Fund for Fungal Infections convened an international expert panel to develop a case definition of CPA for resource-constrained settings. This panel defined CPA as illness for >3 months and all of the following: 1) weight loss, persistent cough, and/or hemoptysis; 2) chest images showing progressive cavitary infiltrates and/or a fungal ball and/or pericavitary fibrosis or infiltrates or pleural thickening; and 3) a positive Aspergillus IgG assay result or other evidence of Aspergillus infection. The proposed definition will facilitate advancements in research, practice, and policy in lower- and middle-income countries as well as in resource-constrained settings.

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