Progressive Multifocal Leukoencephalopathy after Treatment with Nivolumab

Progressive multifocal leukoencephalopathy (PML) is increasingly being reported in patients undergoing immunotherapy. We report a case of progressive multifocal leukoencephalopathy after treatment with nivolumab, a PD-1 blocker that is used to restore impaired T-cell responses in patients with cance...

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Autores principales: Martinot, Martin, Ahle, Guido, Petrosyan, Inesa, Martinez, Camille, Gorun, Dragos M., Mohseni-Zadeh, Mahsa, Fafi-Kremer, Samira, Tebacher-Alt, Martine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2018
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056118/
https://www.ncbi.nlm.nih.gov/pubmed/30016251
http://dx.doi.org/10.3201/eid2408.180460
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author Martinot, Martin
Ahle, Guido
Petrosyan, Inesa
Martinez, Camille
Gorun, Dragos M.
Mohseni-Zadeh, Mahsa
Fafi-Kremer, Samira
Tebacher-Alt, Martine
author_facet Martinot, Martin
Ahle, Guido
Petrosyan, Inesa
Martinez, Camille
Gorun, Dragos M.
Mohseni-Zadeh, Mahsa
Fafi-Kremer, Samira
Tebacher-Alt, Martine
author_sort Martinot, Martin
collection PubMed
description Progressive multifocal leukoencephalopathy (PML) is increasingly being reported in patients undergoing immunotherapy. We report a case of progressive multifocal leukoencephalopathy after treatment with nivolumab, a PD-1 blocker that is used to restore impaired T-cell responses in patients with cancer and infections. Data for 4 other cases were obtained from pharmacovigilance databases.
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spelling pubmed-60561182018-08-01 Progressive Multifocal Leukoencephalopathy after Treatment with Nivolumab Martinot, Martin Ahle, Guido Petrosyan, Inesa Martinez, Camille Gorun, Dragos M. Mohseni-Zadeh, Mahsa Fafi-Kremer, Samira Tebacher-Alt, Martine Emerg Infect Dis Research Letter Progressive multifocal leukoencephalopathy (PML) is increasingly being reported in patients undergoing immunotherapy. We report a case of progressive multifocal leukoencephalopathy after treatment with nivolumab, a PD-1 blocker that is used to restore impaired T-cell responses in patients with cancer and infections. Data for 4 other cases were obtained from pharmacovigilance databases. Centers for Disease Control and Prevention 2018-08 /pmc/articles/PMC6056118/ /pubmed/30016251 http://dx.doi.org/10.3201/eid2408.180460 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Martinot, Martin
Ahle, Guido
Petrosyan, Inesa
Martinez, Camille
Gorun, Dragos M.
Mohseni-Zadeh, Mahsa
Fafi-Kremer, Samira
Tebacher-Alt, Martine
Progressive Multifocal Leukoencephalopathy after Treatment with Nivolumab
title Progressive Multifocal Leukoencephalopathy after Treatment with Nivolumab
title_full Progressive Multifocal Leukoencephalopathy after Treatment with Nivolumab
title_fullStr Progressive Multifocal Leukoencephalopathy after Treatment with Nivolumab
title_full_unstemmed Progressive Multifocal Leukoencephalopathy after Treatment with Nivolumab
title_short Progressive Multifocal Leukoencephalopathy after Treatment with Nivolumab
title_sort progressive multifocal leukoencephalopathy after treatment with nivolumab
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056118/
https://www.ncbi.nlm.nih.gov/pubmed/30016251
http://dx.doi.org/10.3201/eid2408.180460
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