Functional Annotation of Chemical Libraries across Diverse Biological Processes

Chemical-genetic approaches offer the potential for unbiased functional annotation of chemical libraries. Mutations can alter the response of cells to a compound, revealing chemical-genetic interactions that can elucidate a compound’s mode of action. We developed a highly parallel and unbiased yeast...

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Detalles Bibliográficos
Autores principales: Piotrowski, Jeff S., Li, Sheena C., Deshpande, Raamesh, Simpkins, Scott W., Nelson, Justin, Yashiroda, Yoko, Barber, Jacqueline M., Safizadeh, Hamid, Wilson, Erin, Okada, Hiroki, Gebre, Abraham A., Kubo, Karen, Torres, Nikko P., LeBlanc, Marissa A., Andrusiak, Kerry, Okamoto, Reika, Yoshimura, Mami, DeRango-Adem, Eva, van Leeuwen, Jolanda, Shirahige, Katsuhiko, Baryshnikova, Anastasia, Brown, Grant W., Hirano, Hiroyuki, Costanzo, Michael, Andrews, Brenda, Ohya, Yoshikazu, Osada, Hiroyuki, Yoshida, Minoru, Myers, Chad L., Boone, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056180/
https://www.ncbi.nlm.nih.gov/pubmed/28759014
http://dx.doi.org/10.1038/nchembio.2436

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