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Diverse roles of RAD18 and Y-family DNA polymerases in tumorigenesis

Mutagenesis is a hallmark and enabling characteristic of cancer cells. The E3 ubiquitin ligase RAD18 and its downstream effectors, the ‘Y-family’ Trans-Lesion Synthesis (TLS) DNA polymerases, confer DNA damage tolerance at the expense of DNA replication fidelity. Thus, RAD18 and TLS polymerases are...

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Detalles Bibliográficos
Autores principales:	Yang, Yang, Gao, Yanzhe, Zlatanou, Anastasia, Tateishi, Satoshi, Yurchenko, Vyacheslav, Rogozin, Igor B., Vaziri, Cyrus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056224/ https://www.ncbi.nlm.nih.gov/pubmed/29683380 http://dx.doi.org/10.1080/15384101.2018.1456296

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