How small-molecule inhibitors of dengue-virus infection interfere with viral membrane fusion

Dengue virus (DV) is a compact, icosahedrally symmetric, enveloped particle, covered by 90 dimers of envelope protein (E), which mediates viral attachment and membrane fusion. Fusion requires a dimer-to-trimer transition and membrane engagement of hydrophobic ‘fusion loops’. We previously characteri...

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Detalles Bibliográficos
Autores principales: Chao, Luke H, Jang, Jaebong, Johnson, Adam, Nguyen, Anthony, Gray, Nathanael S, Yang, Priscilla L, Harrison, Stephen C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056230/
https://www.ncbi.nlm.nih.gov/pubmed/29999491
http://dx.doi.org/10.7554/eLife.36461

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