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Visualizing conformational dynamics of proteins in solution and at the cell membrane

Conformational dynamics underlie enzyme function, yet are generally inaccessible via traditional structural approaches. FRET has the potential to measure conformational dynamics in vitro and in intact cells, but technical barriers have thus far limited its accuracy, particularly in membrane proteins...

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Detalles Bibliográficos
Autores principales: Gordon, Sharona E, Munari, Mika, Zagotta, William N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056233/
https://www.ncbi.nlm.nih.gov/pubmed/29923827
http://dx.doi.org/10.7554/eLife.37248