Epigenetic and transcriptional dysregulation of VWA2 associated with a MYC-driven oncogenic program in colorectal cancer

VWA2 encodes AMACO, a secreted protein up-regulated in most colorectal carcinomas (CRC), constituting a promising biomarker. The mechanism responsible for its aberrant up-regulation has not been previously described. In this work, we analyzed VWA2 DNA methylation in over 400 primary CRCs. No epigene...

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Detalles Bibliográficos
Autores principales: González, Beatriz, Fece de la Cruz, Ferran, Samuelsson, Johanna Kristina, Alibés, Andreu, Alonso, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056412/
https://www.ncbi.nlm.nih.gov/pubmed/30038405
http://dx.doi.org/10.1038/s41598-018-29378-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056412/
https://www.ncbi.nlm.nih.gov/pubmed/30038405
http://dx.doi.org/10.1038/s41598-018-29378-7

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