The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington’s disease patients

Induced pluripotent stem cells (iPSCs) undergo unlimited self-renewal while maintaining their potential to differentiate into post-mitotic cells with an intact proteome. As such, iPSCs suppress the aggregation of polyQ-expanded huntingtin (HTT), the mutant protein underlying Huntington’s disease (HD...

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Detalles Bibliográficos
Autores principales: Koyuncu, Seda, Saez, Isabel, Lee, Hyun Ju, Gutierrez-Garcia, Ricardo, Pokrzywa, Wojciech, Fatima, Azra, Hoppe, Thorsten, Vilchez, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056416/
https://www.ncbi.nlm.nih.gov/pubmed/30038412
http://dx.doi.org/10.1038/s41467-018-05320-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056416/
https://www.ncbi.nlm.nih.gov/pubmed/30038412
http://dx.doi.org/10.1038/s41467-018-05320-3

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