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Autosomal DIPs for population genetic structure and differentiation analyses of Chinese Xinjiang Kyrgyz ethnic group

In recent years, deletion and insertion polymorphisms (DIPs) were treated as a novel complementary tool with huge potential for forensic applications. In this study, we utilized 30 DIP loci to make a comprehensive research of allele frequency distribution and compute forensic parameters to evaluate...

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Autores principales: Guo, Yuxin, Chen, Chong, Jin, Xiaoye, Cui, Wei, Wei, Yuanyuan, Wang, Hongdan, Kong, Tingting, Mu, Yuling, Zhu, Bofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056483/
https://www.ncbi.nlm.nih.gov/pubmed/30038288
http://dx.doi.org/10.1038/s41598-018-29010-8
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author Guo, Yuxin
Chen, Chong
Jin, Xiaoye
Cui, Wei
Wei, Yuanyuan
Wang, Hongdan
Kong, Tingting
Mu, Yuling
Zhu, Bofeng
author_facet Guo, Yuxin
Chen, Chong
Jin, Xiaoye
Cui, Wei
Wei, Yuanyuan
Wang, Hongdan
Kong, Tingting
Mu, Yuling
Zhu, Bofeng
author_sort Guo, Yuxin
collection PubMed
description In recent years, deletion and insertion polymorphisms (DIPs) were treated as a novel complementary tool with huge potential for forensic applications. In this study, we utilized 30 DIP loci to make a comprehensive research of allele frequency distribution and compute forensic parameters to evaluate the efficiency of forensic applications in the 295 unrelated healthy individuals of Kyrgyz group, and in addition, infer the genetic relationships between Kyrgyz group and 24 other previously studied groups. No significant departures from Hardy-Weinberg equilibrium and linkage disequilibrium were observed at these 30 DIP loci. The combined power of discrimination and the combined probability of exclusion for all 30 DIP loci in Kyrgyz group were 0.9999999999989 and 0.9939, respectively. Furthermore, the results of the interpopulation differentiations, phylogenetic reconstruction, population genetic structure and principal component analyses suggested that Kyrgyz group had relatively close genetic relationships with Kazakh and Uygur groups. However, it was also important to stress that 15 loci were selected out from these 30 DIP loci using the method of selecting ancestry markers, which could be utilized for further ancestry inference study relatively.
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spelling pubmed-60564832018-07-30 Autosomal DIPs for population genetic structure and differentiation analyses of Chinese Xinjiang Kyrgyz ethnic group Guo, Yuxin Chen, Chong Jin, Xiaoye Cui, Wei Wei, Yuanyuan Wang, Hongdan Kong, Tingting Mu, Yuling Zhu, Bofeng Sci Rep Article In recent years, deletion and insertion polymorphisms (DIPs) were treated as a novel complementary tool with huge potential for forensic applications. In this study, we utilized 30 DIP loci to make a comprehensive research of allele frequency distribution and compute forensic parameters to evaluate the efficiency of forensic applications in the 295 unrelated healthy individuals of Kyrgyz group, and in addition, infer the genetic relationships between Kyrgyz group and 24 other previously studied groups. No significant departures from Hardy-Weinberg equilibrium and linkage disequilibrium were observed at these 30 DIP loci. The combined power of discrimination and the combined probability of exclusion for all 30 DIP loci in Kyrgyz group were 0.9999999999989 and 0.9939, respectively. Furthermore, the results of the interpopulation differentiations, phylogenetic reconstruction, population genetic structure and principal component analyses suggested that Kyrgyz group had relatively close genetic relationships with Kazakh and Uygur groups. However, it was also important to stress that 15 loci were selected out from these 30 DIP loci using the method of selecting ancestry markers, which could be utilized for further ancestry inference study relatively. Nature Publishing Group UK 2018-07-23 /pmc/articles/PMC6056483/ /pubmed/30038288 http://dx.doi.org/10.1038/s41598-018-29010-8 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Guo, Yuxin
Chen, Chong
Jin, Xiaoye
Cui, Wei
Wei, Yuanyuan
Wang, Hongdan
Kong, Tingting
Mu, Yuling
Zhu, Bofeng
Autosomal DIPs for population genetic structure and differentiation analyses of Chinese Xinjiang Kyrgyz ethnic group
title Autosomal DIPs for population genetic structure and differentiation analyses of Chinese Xinjiang Kyrgyz ethnic group
title_full Autosomal DIPs for population genetic structure and differentiation analyses of Chinese Xinjiang Kyrgyz ethnic group
title_fullStr Autosomal DIPs for population genetic structure and differentiation analyses of Chinese Xinjiang Kyrgyz ethnic group
title_full_unstemmed Autosomal DIPs for population genetic structure and differentiation analyses of Chinese Xinjiang Kyrgyz ethnic group
title_short Autosomal DIPs for population genetic structure and differentiation analyses of Chinese Xinjiang Kyrgyz ethnic group
title_sort autosomal dips for population genetic structure and differentiation analyses of chinese xinjiang kyrgyz ethnic group
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056483/
https://www.ncbi.nlm.nih.gov/pubmed/30038288
http://dx.doi.org/10.1038/s41598-018-29010-8
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