Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjögren’s Syndrome patients

Cathepsin S (CTSS) activity is elevated in Sjögren’s Syndrome (SS) patient tears. Here we tested whether protease inhibition and cystatin C (Cys C) levels are reduced in SS tears, which could lead to enhanced CTSS-driven degradation of tear proteins. CTSS activity against Cys C, LF and sIgA was test...

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Detalles Bibliográficos
Autores principales: Edman, Maria C., Janga, Srikanth R., Meng, Zhen, Bechtold, Mercy, Chen, Alexander F., Kim, Chongiin, Naman, Luke, Sarma, Arunava, Teekappanavar, Neha, Kim, Alice Y., Madrigal, Sara, Singh, Simranjit, Ortiz, Elizabeth, Christianakis, Stratos, Arkfeld, Daniel G., Mack, Wendy J., Heur, Martin, Stohl, William, Hamm-Alvarez, Sarah F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056496/
https://www.ncbi.nlm.nih.gov/pubmed/30038391
http://dx.doi.org/10.1038/s41598-018-29411-9

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