Cargando…

A systematic dissection of sequence elements determining β-Klotho and FGF interaction and signaling

Endocrine fibroblast growth factors (FGFs) require Klotho transmembrane proteins as necessary co-receptors to activate FGF receptor (FGFR) signaling. In particular, FGF19 and FGF21 function through β-Klotho to regulate glucose and lipid metabolism. Recent research has focused on elucidating how thes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shi, Sally Yu, Lu, Ya-Wen, Richardson, Jason, Min, Xiaoshan, Weiszmann, Jennifer, Richards, William G., Wang, Zhulun, Zhang, Zhongqi, Zhang, Jun, Li, Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056499/ https://www.ncbi.nlm.nih.gov/pubmed/30038432 http://dx.doi.org/10.1038/s41598-018-29396-5

Ejemplares similares

Agonistic β-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions
por: Min, Xiaoshan, et al.
Publicado: (2018)

FGF21 Requires βklotho to Act In Vivo
por: Adams, Andrew C., et al.
Publicado: (2012)

FGF21 Can Be Mimicked In Vitro and In Vivo by a Novel Anti-FGFR1c/β-Klotho Bispecific Protein
por: Smith, Richard, et al.
Publicado: (2013)

Evaluation of FGF-19 and β-klotho as biomarkers in patients with intrahepatic cholestasis of pregnancy
por: Tayyar, Ahter Tanay, et al.
Publicado: (2018)

Biological and pharmacological functions of the FGF19- and FGF21-coreceptor beta klotho
por: Aaldijk, Alexandra S., et al.
Publicado: (2023)

FGF23 Actions on Target Tissues—With and Without Klotho
por: Richter, Beatrice, et al.
Publicado: (2018)

The effect of nephrectomy on Klotho, FGF-23 and bone metabolism
por: Kakareko, Katarzyna, et al.
Publicado: (2017)

FGF-23, Klotho and Vitamin D Levels in Scleroderma
por: AHMADI, Ravan, et al.
Publicado: (2017)

Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability
por: An, Seong J., et al.
Publicado: (2023)

Is there a role in acute kidney injury for FGF23 and Klotho?
por: Mattinzoli, Deborah, et al.
Publicado: (2023)

α-Klotho expression determines nitric oxide synthesis in response to FGF-23 in human aortic endothelial cells
por: Chung, Chih-Ping, et al.
Publicado: (2017)

Feto-maternal cholesterol transport regulated by β-Klotho–FGF15 axis is essential for fetal growth
por: Kobayashi, Kanako, et al.
Publicado: (2023)

Arterial Klotho Expression and FGF23 Effects on Vascular Calcification and Function
por: Lindberg, Karolina, et al.
Publicado: (2013)

Editorial: Endocrine and Paracrine Role of FGF23 and Klotho in Health and Disease
por: Erben, Reinhold G.
Publicado: (2019)

Chronic Over-expression of Fibroblast Growth Factor 21 Increases Bile Acid Biosynthesis by Opposing FGF15/19 Action
por: Zhang, Jun, et al.
Publicado: (2016)

Direct, Acute Effects of Klotho and FGF23 on Vascular Smooth Muscle and Endothelium
por: Six, Isabelle, et al.
Publicado: (2014)

Molecular Mechanisms Underlying Accelerated Aging by Defects in the FGF23-Klotho System
por: Kuro-o, Makoto
Publicado: (2018)

Interactions of sclerostin with FGF23, soluble klotho and vitamin D in renal transplantation
por: Tartaglione, Lida, et al.
Publicado: (2017)

Role of Fibroblast Growth Factor 23 (FGF23) and αKlotho in Cancer
por: Ewendt, Franz, et al.
Publicado: (2021)

The Role of Alterations in Alpha-Klotho and FGF-23 in Kidney Transplantation and Kidney Donation
por: Gupta, Meera, et al.
Publicado: (2022)

Understanding the Stony Bridge between Osteoporosis and Vascular Calcification: Impact of the FGF23/Klotho axis
por: Wei, Xu, et al.
Publicado: (2021)

Central role of the proximal tubular αKlotho/FGF receptor complex in FGF23-regulated phosphate and vitamin D metabolism
por: Takeshita, Ai, et al.
Publicado: (2018)

FGF-23–Klotho signaling stimulates proliferation and prevents vitamin D–induced apoptosis
por: Medici, Damian, et al.
Publicado: (2008)

Prognostic Value and Link to Atrial Fibrillation of Soluble Klotho and FGF23 in Hemodialysis Patients
por: Nowak, Albina, et al.
Publicado: (2014)

Longitudinal FGF23 and Klotho axis characterization in children treated with chronic peritoneal dialysis
por: Cano, Francisco J., et al.
Publicado: (2014)

αKlotho is a Non-Enzymatic Molecular Scaffold for FGF23 Hormone Signaling
por: Chen, Gaozhi, et al.
Publicado: (2018)

FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissue
por: Markan, Kathleen R., et al.
Publicado: (2017)

FGF21 trafficking in intact human cells revealed by cryo-electron tomography with gold nanoparticles
por: Azubel, Maia, et al.
Publicado: (2019)

Klotho/FGF23 and Wnt Signaling as Important Players in the Comorbidities Associated with Chronic Kidney Disease
por: Muñoz-Castañeda, Juan Rafael, et al.
Publicado: (2020)

FGF23, alpha-Klotho and vitamin D mediated calcium-phosphate metabolism in haemodialysis patients
por: Pasaoglu, Ozge Tugce, et al.
Publicado: (2021)

Vitamin D Actions: The Lung Is a Major Target for Vitamin D, FGF23, and Klotho
por: Gayan‐Ramirez, Ghislaine, et al.
Publicado: (2021)

PTH, FGF-23, Klotho and Vitamin D as regulators of calcium and phosphorus: Genetics, epigenetics and beyond
por: Portales-Castillo, Ignacio, et al.
Publicado: (2022)

Genetic Ablation of Fgf23 or Klotho Does not Modulate Experimental Heart Hypertrophy Induced by Pressure Overload
por: Slavic, Svetlana, et al.
Publicado: (2017)

FGF23 and Klotho Levels are Independently Associated with Diabetic Foot Syndrome in Type 2 Diabetes Mellitus
por: Donate-Correa, Javier, et al.
Publicado: (2019)

The Clinical Value of Klotho and FGF23 in Cardiac Valve Calcification Among Patients with Chronic Kidney Disease
por: Chen, Yan, et al.
Publicado: (2021)

Fibroblast Growth Factor 23 (FGF23) and Alpha-Klotho Stimulate Osteoblastic MC3T3.E1 Cell Proliferation and Inhibit Mineralization
por: Shalhoub, V., et al.
Publicado: (2011)

FGF21 mimetic antibody stimulates UCP1-independent brown fat thermogenesis via FGFR1/βKlotho complex in non-adipocytes
por: Chen, Mark Z., et al.
Publicado: (2017)

Association of serum levels of FGF23 and α-Klotho with glomerular filtration rate and proteinuria among cardiac patients
por: Ozeki, Michishige, et al.
Publicado: (2014)

Plasmatic Klotho and FGF23 Levels as Biomarkers of CKD-Associated Cardiac Disease in Type 2 Diabetic Patients
por: Silva, Ana Paula, et al.
Publicado: (2019)

Assessment of Clinical Utility of Assaying FGF-23, Klotho Protein, Osteocalcin, NTX, and Sclerostin in Patients with Primary Hyperparathyroidism
por: Sykała, Monika, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_iviqbms2s0br9bbv1p238t4ah1