The microRNA miR-192/215 family is upregulated in mucinous ovarian carcinomas

Different microRNAs are dysregulated in ovarian cancer where some of them have proved to be valid biomarkers. miRNA profiling analyses have shown that the different histotypes of ovarian carcinoma display differential expression of specific miRNAs. In the present study, we used miRNA-sequencing and...

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Autores principales: Agostini, Antonio, Brunetti, Marta, Davidson, Ben, Tropé, Claes G., Eriksson, Ane Gerda Z., Heim, Sverre, Panagopoulos, Ioannis, Micci, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056508/
https://www.ncbi.nlm.nih.gov/pubmed/30038317
http://dx.doi.org/10.1038/s41598-018-29332-7
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author Agostini, Antonio
Brunetti, Marta
Davidson, Ben
Tropé, Claes G.
Eriksson, Ane Gerda Z.
Heim, Sverre
Panagopoulos, Ioannis
Micci, Francesca
author_facet Agostini, Antonio
Brunetti, Marta
Davidson, Ben
Tropé, Claes G.
Eriksson, Ane Gerda Z.
Heim, Sverre
Panagopoulos, Ioannis
Micci, Francesca
author_sort Agostini, Antonio
collection PubMed
description Different microRNAs are dysregulated in ovarian cancer where some of them have proved to be valid biomarkers. miRNA profiling analyses have shown that the different histotypes of ovarian carcinoma display differential expression of specific miRNAs. In the present study, we used miRNA-sequencing and Real-Time qPCR to detect the expression levels of miRNAs belonging to the miRNA-192/215 family, namely miR-192, miR-194, and miR-215, in different types of ovarian neoplasia, finding that miR-192, miR-194, and miR-215 were upregulated in ovarian carcinomas of the mucinous subtype, but downregulated in other types of carcinoma and in sex cord-stromal tumors. The expression of the said miRNAs was 6-fold higher in mucinous tumors compared to the other histotypes making them candidates for a possible role as diagnostic biomarkers.
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spelling pubmed-60565082018-07-30 The microRNA miR-192/215 family is upregulated in mucinous ovarian carcinomas Agostini, Antonio Brunetti, Marta Davidson, Ben Tropé, Claes G. Eriksson, Ane Gerda Z. Heim, Sverre Panagopoulos, Ioannis Micci, Francesca Sci Rep Article Different microRNAs are dysregulated in ovarian cancer where some of them have proved to be valid biomarkers. miRNA profiling analyses have shown that the different histotypes of ovarian carcinoma display differential expression of specific miRNAs. In the present study, we used miRNA-sequencing and Real-Time qPCR to detect the expression levels of miRNAs belonging to the miRNA-192/215 family, namely miR-192, miR-194, and miR-215, in different types of ovarian neoplasia, finding that miR-192, miR-194, and miR-215 were upregulated in ovarian carcinomas of the mucinous subtype, but downregulated in other types of carcinoma and in sex cord-stromal tumors. The expression of the said miRNAs was 6-fold higher in mucinous tumors compared to the other histotypes making them candidates for a possible role as diagnostic biomarkers. Nature Publishing Group UK 2018-07-23 /pmc/articles/PMC6056508/ /pubmed/30038317 http://dx.doi.org/10.1038/s41598-018-29332-7 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Agostini, Antonio
Brunetti, Marta
Davidson, Ben
Tropé, Claes G.
Eriksson, Ane Gerda Z.
Heim, Sverre
Panagopoulos, Ioannis
Micci, Francesca
The microRNA miR-192/215 family is upregulated in mucinous ovarian carcinomas
title The microRNA miR-192/215 family is upregulated in mucinous ovarian carcinomas
title_full The microRNA miR-192/215 family is upregulated in mucinous ovarian carcinomas
title_fullStr The microRNA miR-192/215 family is upregulated in mucinous ovarian carcinomas
title_full_unstemmed The microRNA miR-192/215 family is upregulated in mucinous ovarian carcinomas
title_short The microRNA miR-192/215 family is upregulated in mucinous ovarian carcinomas
title_sort microrna mir-192/215 family is upregulated in mucinous ovarian carcinomas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056508/
https://www.ncbi.nlm.nih.gov/pubmed/30038317
http://dx.doi.org/10.1038/s41598-018-29332-7
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