Loss of DDHD2, whose mutation causes spastic paraplegia, promotes reactive oxygen species generation and apoptosis

DDHD2/KIAA0725p is a mammalian intracellular phospholipase A(1) that exhibits phospholipase and lipase activities. Mutation of the DDHD2 gene causes hereditary spastic paraplegia (SPG54), an inherited neurological disorder characterized by lower limb spasticity and weakness. Although previous studie...

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Detalles Bibliográficos
Autores principales: Maruyama, Tomohiro, Baba, Takashi, Maemoto, Yuki, Hara-Miyauchi, Chikako, Hasegawa-Ogawa, Minami, Okano, Hirotaka James, Enda, Yuki, Matsumoto, Kei, Arimitsu, Nagisa, Nakao, Kazuki, Hamamoto, Hiroshi, Sekimizu, Kazuhisa, Ohto-Nakanishi, Takayo, Nakanishi, Hiroki, Tokuyama, Takeshi, Yanagi, Shigeru, Tagaya, Mitsuo, Tani, Katsuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056544/
https://www.ncbi.nlm.nih.gov/pubmed/30038238
http://dx.doi.org/10.1038/s41419-018-0815-3

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