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Structure-Guided Redesign Improves NFL HIV Env Trimer Integrity and Identifies an Inter-Protomer Disulfide Permitting Post-Expression Cleavage

Soluble HIV-1 envelope glycoprotein (Env) trimers are under active investigation as vaccine candidates in relevant pre-clinical models. Like SOSIPs, the cleavage-independent native flexibly linked (NFL) trimers are faithful mimics of the Env spike. Here, we analyzed multiple new designs to explore a...

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Detalles Bibliográficos
Autores principales:	Yang, Lifei, Sharma, Shailendra Kumar, Cottrell, Christopher, Guenaga, Javier, Tran, Karen, Wilson, Richard, Behrens, Anna-Janina, Crispin, Max, de Val, Natalia, Wyatt, Richard T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056610/ https://www.ncbi.nlm.nih.gov/pubmed/30065725 http://dx.doi.org/10.3389/fimmu.2018.01631

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