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The Age-Related Perfusion Pattern Measured With Arterial Spin Labeling MRI in Healthy Subjects

Aim: To analyze age-related cerebral blood flow (CBF) using arterial spin labeling (ASL) MRI in healthy subjects with multivariate principal component analysis (PCA). Methods: 50 healthy subjects (mean age 45.8 ± 18.5 years, range 21–85) had 3D structural MRI and pseudo-continuous ASL MRI at resting...

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Autores principales: Zhang, Nan, Gordon, Marc L., Ma, Yilong, Chi, Bradley, Gomar, Jesus J., Peng, Shichun, Kingsley, Peter B., Eidelberg, David, Goldberg, Terry E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056623/
https://www.ncbi.nlm.nih.gov/pubmed/30065646
http://dx.doi.org/10.3389/fnagi.2018.00214
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author Zhang, Nan
Gordon, Marc L.
Ma, Yilong
Chi, Bradley
Gomar, Jesus J.
Peng, Shichun
Kingsley, Peter B.
Eidelberg, David
Goldberg, Terry E.
author_facet Zhang, Nan
Gordon, Marc L.
Ma, Yilong
Chi, Bradley
Gomar, Jesus J.
Peng, Shichun
Kingsley, Peter B.
Eidelberg, David
Goldberg, Terry E.
author_sort Zhang, Nan
collection PubMed
description Aim: To analyze age-related cerebral blood flow (CBF) using arterial spin labeling (ASL) MRI in healthy subjects with multivariate principal component analysis (PCA). Methods: 50 healthy subjects (mean age 45.8 ± 18.5 years, range 21–85) had 3D structural MRI and pseudo-continuous ASL MRI at resting state. The relationship between CBF and age was examined with voxel-based univariate analysis using multiple regression and two-sample t-test (median age 41.8 years as a cut-off). An age-related CBF pattern was identified using multivariate PCA. Results: Age correlated negatively with CBF especially anteriorly and in the cerebellum. After adjusting by global value, CBF was relatively decreased with aging in certain regions and relatively increased in others. The age-related CBF pattern showed relative reductions in frontal and parietal areas and cerebellum, and covarying increases in temporal and occipital areas. Subject scores of this pattern correlated negatively with age (R(2) = 0.588; P < 0.001) and discriminated between the older and younger subgroups (P < 0.001). Conclusion: A distinct age-related CBF pattern can be identified with multivariate PCA using ASL MRI.
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spelling pubmed-60566232018-07-31 The Age-Related Perfusion Pattern Measured With Arterial Spin Labeling MRI in Healthy Subjects Zhang, Nan Gordon, Marc L. Ma, Yilong Chi, Bradley Gomar, Jesus J. Peng, Shichun Kingsley, Peter B. Eidelberg, David Goldberg, Terry E. Front Aging Neurosci Neuroscience Aim: To analyze age-related cerebral blood flow (CBF) using arterial spin labeling (ASL) MRI in healthy subjects with multivariate principal component analysis (PCA). Methods: 50 healthy subjects (mean age 45.8 ± 18.5 years, range 21–85) had 3D structural MRI and pseudo-continuous ASL MRI at resting state. The relationship between CBF and age was examined with voxel-based univariate analysis using multiple regression and two-sample t-test (median age 41.8 years as a cut-off). An age-related CBF pattern was identified using multivariate PCA. Results: Age correlated negatively with CBF especially anteriorly and in the cerebellum. After adjusting by global value, CBF was relatively decreased with aging in certain regions and relatively increased in others. The age-related CBF pattern showed relative reductions in frontal and parietal areas and cerebellum, and covarying increases in temporal and occipital areas. Subject scores of this pattern correlated negatively with age (R(2) = 0.588; P < 0.001) and discriminated between the older and younger subgroups (P < 0.001). Conclusion: A distinct age-related CBF pattern can be identified with multivariate PCA using ASL MRI. Frontiers Media S.A. 2018-07-17 /pmc/articles/PMC6056623/ /pubmed/30065646 http://dx.doi.org/10.3389/fnagi.2018.00214 Text en Copyright © 2018 Zhang, Gordon, Ma, Chi, Gomar, Peng, Kingsley, Eidelberg and Goldberg. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zhang, Nan
Gordon, Marc L.
Ma, Yilong
Chi, Bradley
Gomar, Jesus J.
Peng, Shichun
Kingsley, Peter B.
Eidelberg, David
Goldberg, Terry E.
The Age-Related Perfusion Pattern Measured With Arterial Spin Labeling MRI in Healthy Subjects
title The Age-Related Perfusion Pattern Measured With Arterial Spin Labeling MRI in Healthy Subjects
title_full The Age-Related Perfusion Pattern Measured With Arterial Spin Labeling MRI in Healthy Subjects
title_fullStr The Age-Related Perfusion Pattern Measured With Arterial Spin Labeling MRI in Healthy Subjects
title_full_unstemmed The Age-Related Perfusion Pattern Measured With Arterial Spin Labeling MRI in Healthy Subjects
title_short The Age-Related Perfusion Pattern Measured With Arterial Spin Labeling MRI in Healthy Subjects
title_sort age-related perfusion pattern measured with arterial spin labeling mri in healthy subjects
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056623/
https://www.ncbi.nlm.nih.gov/pubmed/30065646
http://dx.doi.org/10.3389/fnagi.2018.00214
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