Novel Nrf2-Inducer Prevents Mitochondrial Defects and Oxidative Stress in Friedreich’s Ataxia Models

Friedreich’s Ataxia (FRDA) is an autosomal recessive neurodegenerative disorder, affecting dorsal root ganglia (DRG), cerebellar dentate nuclei and heart. It is caused by a GAA repeat expansion mutation within the frataxin gene (FXN). This impedes FXN transcription resulting in a progressive decreas...

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Detalles Bibliográficos
Autores principales: Abeti, Rosella, Baccaro, Annalisa, Esteras, Noemi, Giunti, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056642/
https://www.ncbi.nlm.nih.gov/pubmed/30065630
http://dx.doi.org/10.3389/fncel.2018.00188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056642/
https://www.ncbi.nlm.nih.gov/pubmed/30065630
http://dx.doi.org/10.3389/fncel.2018.00188

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