Cargando…

196G/A of the Brain-Derived Neurotrophic Factor Gene Polymorphisms Predicts Suicidal Behavior in Schizophrenia Patients

OBJECTIVE: Brain-derived neurotrophic factor (BDNF) has possible neurobiologic impact on etiology of schizophrenia. We hypothesized that the specific allele or the genotype such as two single nucleotide polymorphisms (SNPs) , 196G/A (rs6265), 11757G/C(rs16917204) is associated with schizophrenia or...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Eun-Jeong, Kim, Yong-Ku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neuropsychiatric Association 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056694/
https://www.ncbi.nlm.nih.gov/pubmed/29898578
http://dx.doi.org/10.30773/pi.2018.02.27
_version_ 1783341387202166784
author Kim, Eun-Jeong
Kim, Yong-Ku
author_facet Kim, Eun-Jeong
Kim, Yong-Ku
author_sort Kim, Eun-Jeong
collection PubMed
description OBJECTIVE: Brain-derived neurotrophic factor (BDNF) has possible neurobiologic impact on etiology of schizophrenia. We hypothesized that the specific allele or the genotype such as two single nucleotide polymorphisms (SNPs) , 196G/A (rs6265), 11757G/C(rs16917204) is associated with schizophrenia or its clinical features. METHODS: 241 normal controls and 157 schizophrenia patients are included. The differences in allele or genotype distribution for the patients and normal controls were analyzed. We also analyzed clinical variables among patients. RESULTS: We found no significant difference in genotype or allele distributions of two studied SNPs between the patient group and the control group. However, history of suicide attempt was relatively higher in patients with genotype with A allele, compared to patients with genotype G/G for 196G/A (p-value=0.045). CONCLUSION: Our results suggest that it is possible to use BDNF gene allele and genotype as a predictor for suicide attempt in schizophrenia patients. It can help manage the schizophrenia patients regarding suicidal behavior and furthermore, mortality.
format Online
Article
Text
id pubmed-6056694
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Korean Neuropsychiatric Association
record_format MEDLINE/PubMed
spelling pubmed-60566942018-08-03 196G/A of the Brain-Derived Neurotrophic Factor Gene Polymorphisms Predicts Suicidal Behavior in Schizophrenia Patients Kim, Eun-Jeong Kim, Yong-Ku Psychiatry Investig Original Article OBJECTIVE: Brain-derived neurotrophic factor (BDNF) has possible neurobiologic impact on etiology of schizophrenia. We hypothesized that the specific allele or the genotype such as two single nucleotide polymorphisms (SNPs) , 196G/A (rs6265), 11757G/C(rs16917204) is associated with schizophrenia or its clinical features. METHODS: 241 normal controls and 157 schizophrenia patients are included. The differences in allele or genotype distribution for the patients and normal controls were analyzed. We also analyzed clinical variables among patients. RESULTS: We found no significant difference in genotype or allele distributions of two studied SNPs between the patient group and the control group. However, history of suicide attempt was relatively higher in patients with genotype with A allele, compared to patients with genotype G/G for 196G/A (p-value=0.045). CONCLUSION: Our results suggest that it is possible to use BDNF gene allele and genotype as a predictor for suicide attempt in schizophrenia patients. It can help manage the schizophrenia patients regarding suicidal behavior and furthermore, mortality. Korean Neuropsychiatric Association 2018-07 2018-06-15 /pmc/articles/PMC6056694/ /pubmed/29898578 http://dx.doi.org/10.30773/pi.2018.02.27 Text en Copyright © 2018 Korean Neuropsychiatric Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Eun-Jeong
Kim, Yong-Ku
196G/A of the Brain-Derived Neurotrophic Factor Gene Polymorphisms Predicts Suicidal Behavior in Schizophrenia Patients
title 196G/A of the Brain-Derived Neurotrophic Factor Gene Polymorphisms Predicts Suicidal Behavior in Schizophrenia Patients
title_full 196G/A of the Brain-Derived Neurotrophic Factor Gene Polymorphisms Predicts Suicidal Behavior in Schizophrenia Patients
title_fullStr 196G/A of the Brain-Derived Neurotrophic Factor Gene Polymorphisms Predicts Suicidal Behavior in Schizophrenia Patients
title_full_unstemmed 196G/A of the Brain-Derived Neurotrophic Factor Gene Polymorphisms Predicts Suicidal Behavior in Schizophrenia Patients
title_short 196G/A of the Brain-Derived Neurotrophic Factor Gene Polymorphisms Predicts Suicidal Behavior in Schizophrenia Patients
title_sort 196g/a of the brain-derived neurotrophic factor gene polymorphisms predicts suicidal behavior in schizophrenia patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056694/
https://www.ncbi.nlm.nih.gov/pubmed/29898578
http://dx.doi.org/10.30773/pi.2018.02.27
work_keys_str_mv AT kimeunjeong 196gaofthebrainderivedneurotrophicfactorgenepolymorphismspredictssuicidalbehaviorinschizophreniapatients
AT kimyongku 196gaofthebrainderivedneurotrophicfactorgenepolymorphismspredictssuicidalbehaviorinschizophreniapatients