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Mitochondrial DNA replication in mammalian cells: overview of the pathway

Mammalian mitochondria contain multiple copies of a circular, double-stranded DNA genome and a dedicated DNA replication machinery is required for its maintenance. Many disease-causing mutations affect mitochondrial replication factors and a detailed understanding of the replication process may help...

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Detalles Bibliográficos
Autor principal: Falkenberg, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056714/
https://www.ncbi.nlm.nih.gov/pubmed/29880722
http://dx.doi.org/10.1042/EBC20170100
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author Falkenberg, Maria
author_facet Falkenberg, Maria
author_sort Falkenberg, Maria
collection PubMed
description Mammalian mitochondria contain multiple copies of a circular, double-stranded DNA genome and a dedicated DNA replication machinery is required for its maintenance. Many disease-causing mutations affect mitochondrial replication factors and a detailed understanding of the replication process may help to explain the pathogenic mechanisms underlying a number of mitochondrial diseases. We here give a brief overview of DNA replication in mammalian mitochondria, describing our current understanding of this process and some unanswered questions remaining.
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spelling pubmed-60567142018-08-08 Mitochondrial DNA replication in mammalian cells: overview of the pathway Falkenberg, Maria Essays Biochem Review Articles Mammalian mitochondria contain multiple copies of a circular, double-stranded DNA genome and a dedicated DNA replication machinery is required for its maintenance. Many disease-causing mutations affect mitochondrial replication factors and a detailed understanding of the replication process may help to explain the pathogenic mechanisms underlying a number of mitochondrial diseases. We here give a brief overview of DNA replication in mammalian mitochondria, describing our current understanding of this process and some unanswered questions remaining. Portland Press Ltd. 2018-06-07 /pmc/articles/PMC6056714/ /pubmed/29880722 http://dx.doi.org/10.1042/EBC20170100 Text en © 2018 The Author(s). https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Review Articles
Falkenberg, Maria
Mitochondrial DNA replication in mammalian cells: overview of the pathway
title Mitochondrial DNA replication in mammalian cells: overview of the pathway
title_full Mitochondrial DNA replication in mammalian cells: overview of the pathway
title_fullStr Mitochondrial DNA replication in mammalian cells: overview of the pathway
title_full_unstemmed Mitochondrial DNA replication in mammalian cells: overview of the pathway
title_short Mitochondrial DNA replication in mammalian cells: overview of the pathway
title_sort mitochondrial dna replication in mammalian cells: overview of the pathway
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056714/
https://www.ncbi.nlm.nih.gov/pubmed/29880722
http://dx.doi.org/10.1042/EBC20170100
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