Cargando…

Transgelin-2 is a novel target of KRAS-ERK signaling involved in the development of pancreatic cancer

BACKGROUND: The KRAS mutation is the driving force of pancreatic ductal adenocarcinoma (PDAC). Downstream effectors of KRAS signal pathways are crucial to the development of PDAC. The purpose of this study was to investigate the relationship between KRAS mutation and transgelin-2. Transgelin-2 is hi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Yan, Peng, Wenfang, He, Weiwei, Luo, Man, Chang, Guilin, Shen, Jiping, Zhao, Xiaoping, Hu, Yu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056937/ https://www.ncbi.nlm.nih.gov/pubmed/30041673 http://dx.doi.org/10.1186/s13046-018-0818-z

Ejemplares similares

Role of transgelin-2 in diabetes-associated pancreatic ductal adenocarcinoma
por: Sun, Yan, et al.
Publicado: (2017)

Evolution and function of calponin and transgelin
por: Hsieh, Tzu-Bou, et al.
Publicado: (2023)

Transgelin in bladder cancer: A potential biomarker and therapeutic target
por: Li, Wei-Ming, et al.
Publicado: (2019)

Deglycosylated Azithromycin Targets Transgelin to Enhance Intestinal Smooth Muscle Function
por: Zhong, Weilong, et al.
Publicado: (2020)

Transgelin Up-Regulation in Obstructive Nephropathy
por: Karagianni, Fani, et al.
Publicado: (2013)

Salvianolic acid A targeting the transgelin-actin complex to enhance vasoconstriction
por: Zhong, Weilong, et al.
Publicado: (2018)

Transgelin-2 Involves in the Apoptosis of Colorectal Cancer Cells Induced by Tanshinone-IIA
por: Zhang, Yingru, et al.
Publicado: (2022)

Differential Expression of Drosophila Transgelins Throughout Development
por: Vakaloglou, Katerina M., et al.
Publicado: (2021)

Transgelin interacts with PARP1 in human colon cancer cells
por: Lew, Zhen-xian, et al.
Publicado: (2020)

Transgelin as a potential target in the reversibility of pulmonary arterial hypertension secondary to congenital heart disease
por: Huang, Li, et al.
Publicado: (2018)

Transgelin-expressing myofibroblasts orchestrate ventral midline closure through TGFβ signalling
por: Aldeiri, Bashar, et al.
Publicado: (2017)

Transgelin-2: A Double-Edged Sword in Immunity and Cancer Metastasis
por: Kim, Hye-Ran, et al.
Publicado: (2021)

Targeting KRAS in Pancreatic Cancer
por: Cowzer, Darren, et al.
Publicado: (2022)

Expression of Cofilin-1 and Transgelin in Esophageal Squamous Cell Carcinoma
por: Zhang, Yan, et al.
Publicado: (2015)

Transgelins: Cytoskeletal Associated Proteins Implicated in the Metastasis of Colorectal Cancer
por: Liu, Jingwen, et al.
Publicado: (2020)

Oncogenic KRAS signalling in pancreatic cancer
por: Eser, S, et al.
Publicado: (2014)

Dysregulation of KRAS signaling in pancreatic cancer is not associated with KRAS mutations and outcome
por: Lemstrova, Radmila, et al.
Publicado: (2017)

Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility
por: Zhou, Hui-min, et al.
Publicado: (2016)

The KRAS-regulated kinome identifies WEE1 and ERK coinhibition as a potential therapeutic strategy in KRAS-mutant pancreatic cancer
por: Diehl, J. Nathaniel, et al.
Publicado: (2021)

Transgelin gene is frequently downregulated by promoter DNA hypermethylation in breast cancer
por: Sayar, Nilufer, et al.
Publicado: (2015)

Transgelin-2 in Multiple Myeloma: A New Marker of Renal Impairment?
por: Woziwodzka, Karolina, et al.
Publicado: (2021)

Elevated transgelin/TNS1 expression is a potential biomarker in human colorectal cancer
por: Zhou, Huimin, et al.
Publicado: (2017)

Transgelin: a new gene involved in LDL endocytosis identified by a genome-wide CRISPR-Cas9 screen
por: Lucero, Diego, et al.
Publicado: (2021)

Transgelin-2 in B-Cells Controls T-Cell Activation by Stabilizing T Cell - B Cell Conjugates
por: Na, Bo-Ra, et al.
Publicado: (2016)

[Retracted] MicroRNA‑326 inhibits melanoma progression by targeting KRAS and suppressing the AKT and ERK signalling pathways
por: Kang, Kang, et al.
Publicado: (2023)

Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy
por: Kim, Hye-Ran, et al.
Publicado: (2021)

Smad3 signalling affects high glucose‐induced podocyte injury via regulation of the cytoskeletal protein transgelin
por: Jiang, Lina, et al.
Publicado: (2020)

Bioinformatics analysis reveals the roles of cytoskeleton protein transgelin in occurrence and development of proteinuria
por: Ding, Yingxue, et al.
Publicado: (2021)

Transgelin promotes ferroptosis to inhibit the malignant progression of esophageal squamous cell carcinoma
por: Chen, Qiuyu, et al.
Publicado: (2023)

CUX1 Enhances Pancreatic Cancer Formation by Synergizing with KRAS and Inducing MEK/ERK-Dependent Proliferation
por: Griesmann, Heidi, et al.
Publicado: (2021)

Phosphorylation of Ser6 in hnRNPA1 by S6K2 regulates glucose metabolism and cell growth in colorectal cancer
por: Sun, Yan, et al.
Publicado: (2017)

Caffeine and Rolipram Affect Smad Signalling and TGF-β1 Stimulated CTGF and Transgelin Expression in Lung Epithelial Cells
por: Fehrholz, Markus, et al.
Publicado: (2014)

Transgelin exacerbates pulmonary artery smooth muscle cell dysfunction in shunt‐related pulmonary arterial hypertension
por: Zhou, Jing‐jing, et al.
Publicado: (2022)

Purification and properties of transgelin: a transformation and shape change sensitive actin-gelling protein
Publicado: (1993)

Transgelin Contributes to a Poor Response of Metastatic Renal Cell Carcinoma to Sunitinib Treatment
por: Bouchalova, Pavla, et al.
Publicado: (2021)

Beyond KRAS: Practical Molecular Targets in Pancreatic Adenocarcinoma
por: Grinshpun, Albert, et al.
Publicado: (2019)

Targeting Mutant KRAS in Pancreatic Cancer: Futile or Promising?
por: Nollmann, Friederike Inga, et al.
Publicado: (2020)

TGF-β-induced transgelin promotes bladder cancer metastasis by regulating epithelial-mesenchymal transition and invadopodia formation
por: Chen, Zhicong, et al.
Publicado: (2019)

Targeting protein methylation in pancreatic cancer cells results in KRAS signaling imbalance and inhibition of autophagy
por: Montenegro, María F., et al.
Publicado: (2023)

Oncogenic transgelin-2 is differentially regulated in isocitrate dehydrogenase wild-type vs. mutant gliomas
por: Beyer, Sasha J., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_hk07omvcnmun3blmvgketvvson