Cargando…
Lung Cancer Screening with Low-Dose CT in Female Never Smokers: Retrospective Cohort Study with Long-term National Data Follow-up
PURPOSE: Because of growing concerns about lung cancer in female never smokers, chest low-dose computed tomography (LDCT) screening is often performed although it has never shown clinical benefits. We examinewhether or not female never smokers really need annual LDCT screening when the initial LDCT...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Cancer Association
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056956/ https://www.ncbi.nlm.nih.gov/pubmed/28724283 http://dx.doi.org/10.4143/crt.2017.312 |
_version_ | 1783341425379770368 |
---|---|
author | Kim, Hyae Young Jung, Kyu-Won Lim, Kun Young Lee, Soo-Hyun Jun, Jae Kwan Kim, Jeongseon Hwangbo, Bin Lee, Jin Soo |
author_facet | Kim, Hyae Young Jung, Kyu-Won Lim, Kun Young Lee, Soo-Hyun Jun, Jae Kwan Kim, Jeongseon Hwangbo, Bin Lee, Jin Soo |
author_sort | Kim, Hyae Young |
collection | PubMed |
description | PURPOSE: Because of growing concerns about lung cancer in female never smokers, chest low-dose computed tomography (LDCT) screening is often performed although it has never shown clinical benefits. We examinewhether or not female never smokers really need annual LDCT screening when the initial LDCT showed negative findings. MATERIALS AND METHODS: This retrospective cohort study included 4,365 female never smokers aged 40 to 79 years who performed initial LDCT from Aug 2002 to Dec 2007. Lung cancer diagnosis was identified from the Korea Central Cancer Registry Database registered until December 31, 2013. We calculated the incidence, cumulative probability, and standardized incidence ratio (SIR) of lung cancer by Lung Imaging Reporting and Data System (Lung-RADS) categories showed on initial LDCT. RESULTS: After median follow-up of 9.69 years, 22 (0.5%) had lung cancer. Lung cancer incidence for Lung-RADS category 4 was 1,848.4 (95% confidence interval [CI], 1,132.4 to 3,017.2) per 100,000 person-years and 16.4 (95% CI, 7.4 to 36.4) for categories 1, 2, and 3 combined. The cumulative probability of lung cancer for category 4 was 10.6% at 5 years and 14.8% at 10 years while they were 0.07% and 0.17% when categories 1, 2, and 3 were combined. The SIR for subjects with category 4 was 43.80 (95% CI, 25.03 to 71.14), which was much higher than 0.47 (95% CI, 0.17 to 1.02) for categories 1, 2, and 3 combined. CONCLUSION: Considering the low risk of lung cancer development in female never smokers, it seems unnecessary to repeat annual LDCT screening for at least 5 years or even longer unless the initial LDCT showed Lung-RADS category 4 findings. |
format | Online Article Text |
id | pubmed-6056956 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Korean Cancer Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-60569562018-07-27 Lung Cancer Screening with Low-Dose CT in Female Never Smokers: Retrospective Cohort Study with Long-term National Data Follow-up Kim, Hyae Young Jung, Kyu-Won Lim, Kun Young Lee, Soo-Hyun Jun, Jae Kwan Kim, Jeongseon Hwangbo, Bin Lee, Jin Soo Cancer Res Treat Original Article PURPOSE: Because of growing concerns about lung cancer in female never smokers, chest low-dose computed tomography (LDCT) screening is often performed although it has never shown clinical benefits. We examinewhether or not female never smokers really need annual LDCT screening when the initial LDCT showed negative findings. MATERIALS AND METHODS: This retrospective cohort study included 4,365 female never smokers aged 40 to 79 years who performed initial LDCT from Aug 2002 to Dec 2007. Lung cancer diagnosis was identified from the Korea Central Cancer Registry Database registered until December 31, 2013. We calculated the incidence, cumulative probability, and standardized incidence ratio (SIR) of lung cancer by Lung Imaging Reporting and Data System (Lung-RADS) categories showed on initial LDCT. RESULTS: After median follow-up of 9.69 years, 22 (0.5%) had lung cancer. Lung cancer incidence for Lung-RADS category 4 was 1,848.4 (95% confidence interval [CI], 1,132.4 to 3,017.2) per 100,000 person-years and 16.4 (95% CI, 7.4 to 36.4) for categories 1, 2, and 3 combined. The cumulative probability of lung cancer for category 4 was 10.6% at 5 years and 14.8% at 10 years while they were 0.07% and 0.17% when categories 1, 2, and 3 were combined. The SIR for subjects with category 4 was 43.80 (95% CI, 25.03 to 71.14), which was much higher than 0.47 (95% CI, 0.17 to 1.02) for categories 1, 2, and 3 combined. CONCLUSION: Considering the low risk of lung cancer development in female never smokers, it seems unnecessary to repeat annual LDCT screening for at least 5 years or even longer unless the initial LDCT showed Lung-RADS category 4 findings. Korean Cancer Association 2018-07 2017-07-17 /pmc/articles/PMC6056956/ /pubmed/28724283 http://dx.doi.org/10.4143/crt.2017.312 Text en Copyright © 2018 by the Korean Cancer Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Hyae Young Jung, Kyu-Won Lim, Kun Young Lee, Soo-Hyun Jun, Jae Kwan Kim, Jeongseon Hwangbo, Bin Lee, Jin Soo Lung Cancer Screening with Low-Dose CT in Female Never Smokers: Retrospective Cohort Study with Long-term National Data Follow-up |
title | Lung Cancer Screening with Low-Dose CT in Female Never Smokers: Retrospective Cohort Study with Long-term National Data Follow-up |
title_full | Lung Cancer Screening with Low-Dose CT in Female Never Smokers: Retrospective Cohort Study with Long-term National Data Follow-up |
title_fullStr | Lung Cancer Screening with Low-Dose CT in Female Never Smokers: Retrospective Cohort Study with Long-term National Data Follow-up |
title_full_unstemmed | Lung Cancer Screening with Low-Dose CT in Female Never Smokers: Retrospective Cohort Study with Long-term National Data Follow-up |
title_short | Lung Cancer Screening with Low-Dose CT in Female Never Smokers: Retrospective Cohort Study with Long-term National Data Follow-up |
title_sort | lung cancer screening with low-dose ct in female never smokers: retrospective cohort study with long-term national data follow-up |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056956/ https://www.ncbi.nlm.nih.gov/pubmed/28724283 http://dx.doi.org/10.4143/crt.2017.312 |
work_keys_str_mv | AT kimhyaeyoung lungcancerscreeningwithlowdosectinfemaleneversmokersretrospectivecohortstudywithlongtermnationaldatafollowup AT jungkyuwon lungcancerscreeningwithlowdosectinfemaleneversmokersretrospectivecohortstudywithlongtermnationaldatafollowup AT limkunyoung lungcancerscreeningwithlowdosectinfemaleneversmokersretrospectivecohortstudywithlongtermnationaldatafollowup AT leesoohyun lungcancerscreeningwithlowdosectinfemaleneversmokersretrospectivecohortstudywithlongtermnationaldatafollowup AT junjaekwan lungcancerscreeningwithlowdosectinfemaleneversmokersretrospectivecohortstudywithlongtermnationaldatafollowup AT kimjeongseon lungcancerscreeningwithlowdosectinfemaleneversmokersretrospectivecohortstudywithlongtermnationaldatafollowup AT hwangbobin lungcancerscreeningwithlowdosectinfemaleneversmokersretrospectivecohortstudywithlongtermnationaldatafollowup AT leejinsoo lungcancerscreeningwithlowdosectinfemaleneversmokersretrospectivecohortstudywithlongtermnationaldatafollowup |