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Phase 1 Studies of Poziotinib, an Irreversible Pan-HER Tyrosine Kinase Inhibitor in Patients with Advanced Solid Tumors

PURPOSE: Poziotinib, a pan-human epidermal growth factor receptor 2 (HER) tyrosine kinase inhibitor, has shown potent activity againstwild type of epidermal growth factorreceptor(EGFR) family kinases including EGFR, HER2, and HER4 and EGFR-mutant cells in vitro. Two phase I studies were conducted to...

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Detalles Bibliográficos
Autores principales:	Kim, Tae Min, Lee, Keun-Wook, Oh, Do-Youn, Lee, Jong-Seok, Im, Seock-Ah, Kim, Dong-Wan, Han, Sae-Won, Kim, Yu Jung, Kim, Tae-You, Kim, Jee Hyun, Han, Hyesun, Kim, Woo Ho, Bang, Yung-Jue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Cancer Association 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056959/ https://www.ncbi.nlm.nih.gov/pubmed/28859471 http://dx.doi.org/10.4143/crt.2017.303

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