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Lobectomy for lung cancer in a myelodysplastic syndrome patient with decreasing platelet aggregation: report of a case
BACKGROUND: Myelodysplastic syndromes (MDS) are clonal stem cell disorders of the bone marrow. Most patients with MDS have a high risk of bleeding. Thrombocytopenia and defective platelet aggregation contribute to bleeding. We report a surgical case of a patient with lung cancer concomitant with MDS...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057011/ https://www.ncbi.nlm.nih.gov/pubmed/30041670 http://dx.doi.org/10.1186/s13019-018-0777-7 |
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author | Koezuka, Satoshi Hata, Yoshinobu Otsuka, Hajime Makino, Takashi Azuma, Yoko Azumi, Takashi Anami, Yoichi Natori, Kazuhiko Iyoda, Akira |
author_facet | Koezuka, Satoshi Hata, Yoshinobu Otsuka, Hajime Makino, Takashi Azuma, Yoko Azumi, Takashi Anami, Yoichi Natori, Kazuhiko Iyoda, Akira |
author_sort | Koezuka, Satoshi |
collection | PubMed |
description | BACKGROUND: Myelodysplastic syndromes (MDS) are clonal stem cell disorders of the bone marrow. Most patients with MDS have a high risk of bleeding. Thrombocytopenia and defective platelet aggregation contribute to bleeding. We report a surgical case of a patient with lung cancer concomitant with MDS. CASE PRESENTATION: A 72-year-old man presented to our hospital because of an abnormal shadow on chest x-ray suggesting a primary lung cancer. A peripheral blood smear examination found giant platelets without thrombocytopenia. He was diagnosed with MDS by bone marrow biopsy, and showed defective platelet aggregation despite a normal bleeding time. The patient underwent left lower lobectomy and transfusion of platelets because of chest wall bleeding. CONCLUSIONS: We demonstrated that ordering platelet preparations might be desirable for an MDS patient with defective platelet aggregation who will undergo surgery, even for a normal platelet count and bleeding time. |
format | Online Article Text |
id | pubmed-6057011 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-60570112018-07-30 Lobectomy for lung cancer in a myelodysplastic syndrome patient with decreasing platelet aggregation: report of a case Koezuka, Satoshi Hata, Yoshinobu Otsuka, Hajime Makino, Takashi Azuma, Yoko Azumi, Takashi Anami, Yoichi Natori, Kazuhiko Iyoda, Akira J Cardiothorac Surg Case Report BACKGROUND: Myelodysplastic syndromes (MDS) are clonal stem cell disorders of the bone marrow. Most patients with MDS have a high risk of bleeding. Thrombocytopenia and defective platelet aggregation contribute to bleeding. We report a surgical case of a patient with lung cancer concomitant with MDS. CASE PRESENTATION: A 72-year-old man presented to our hospital because of an abnormal shadow on chest x-ray suggesting a primary lung cancer. A peripheral blood smear examination found giant platelets without thrombocytopenia. He was diagnosed with MDS by bone marrow biopsy, and showed defective platelet aggregation despite a normal bleeding time. The patient underwent left lower lobectomy and transfusion of platelets because of chest wall bleeding. CONCLUSIONS: We demonstrated that ordering platelet preparations might be desirable for an MDS patient with defective platelet aggregation who will undergo surgery, even for a normal platelet count and bleeding time. BioMed Central 2018-07-24 /pmc/articles/PMC6057011/ /pubmed/30041670 http://dx.doi.org/10.1186/s13019-018-0777-7 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Koezuka, Satoshi Hata, Yoshinobu Otsuka, Hajime Makino, Takashi Azuma, Yoko Azumi, Takashi Anami, Yoichi Natori, Kazuhiko Iyoda, Akira Lobectomy for lung cancer in a myelodysplastic syndrome patient with decreasing platelet aggregation: report of a case |
title | Lobectomy for lung cancer in a myelodysplastic syndrome patient with decreasing platelet aggregation: report of a case |
title_full | Lobectomy for lung cancer in a myelodysplastic syndrome patient with decreasing platelet aggregation: report of a case |
title_fullStr | Lobectomy for lung cancer in a myelodysplastic syndrome patient with decreasing platelet aggregation: report of a case |
title_full_unstemmed | Lobectomy for lung cancer in a myelodysplastic syndrome patient with decreasing platelet aggregation: report of a case |
title_short | Lobectomy for lung cancer in a myelodysplastic syndrome patient with decreasing platelet aggregation: report of a case |
title_sort | lobectomy for lung cancer in a myelodysplastic syndrome patient with decreasing platelet aggregation: report of a case |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057011/ https://www.ncbi.nlm.nih.gov/pubmed/30041670 http://dx.doi.org/10.1186/s13019-018-0777-7 |
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