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Lobectomy for lung cancer in a myelodysplastic syndrome patient with decreasing platelet aggregation: report of a case

BACKGROUND: Myelodysplastic syndromes (MDS) are clonal stem cell disorders of the bone marrow. Most patients with MDS have a high risk of bleeding. Thrombocytopenia and defective platelet aggregation contribute to bleeding. We report a surgical case of a patient with lung cancer concomitant with MDS...

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Autores principales: Koezuka, Satoshi, Hata, Yoshinobu, Otsuka, Hajime, Makino, Takashi, Azuma, Yoko, Azumi, Takashi, Anami, Yoichi, Natori, Kazuhiko, Iyoda, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057011/
https://www.ncbi.nlm.nih.gov/pubmed/30041670
http://dx.doi.org/10.1186/s13019-018-0777-7
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author Koezuka, Satoshi
Hata, Yoshinobu
Otsuka, Hajime
Makino, Takashi
Azuma, Yoko
Azumi, Takashi
Anami, Yoichi
Natori, Kazuhiko
Iyoda, Akira
author_facet Koezuka, Satoshi
Hata, Yoshinobu
Otsuka, Hajime
Makino, Takashi
Azuma, Yoko
Azumi, Takashi
Anami, Yoichi
Natori, Kazuhiko
Iyoda, Akira
author_sort Koezuka, Satoshi
collection PubMed
description BACKGROUND: Myelodysplastic syndromes (MDS) are clonal stem cell disorders of the bone marrow. Most patients with MDS have a high risk of bleeding. Thrombocytopenia and defective platelet aggregation contribute to bleeding. We report a surgical case of a patient with lung cancer concomitant with MDS. CASE PRESENTATION: A 72-year-old man presented to our hospital because of an abnormal shadow on chest x-ray suggesting a primary lung cancer. A peripheral blood smear examination found giant platelets without thrombocytopenia. He was diagnosed with MDS by bone marrow biopsy, and showed defective platelet aggregation despite a normal bleeding time. The patient underwent left lower lobectomy and transfusion of platelets because of chest wall bleeding. CONCLUSIONS: We demonstrated that ordering platelet preparations might be desirable for an MDS patient with defective platelet aggregation who will undergo surgery, even for a normal platelet count and bleeding time.
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spelling pubmed-60570112018-07-30 Lobectomy for lung cancer in a myelodysplastic syndrome patient with decreasing platelet aggregation: report of a case Koezuka, Satoshi Hata, Yoshinobu Otsuka, Hajime Makino, Takashi Azuma, Yoko Azumi, Takashi Anami, Yoichi Natori, Kazuhiko Iyoda, Akira J Cardiothorac Surg Case Report BACKGROUND: Myelodysplastic syndromes (MDS) are clonal stem cell disorders of the bone marrow. Most patients with MDS have a high risk of bleeding. Thrombocytopenia and defective platelet aggregation contribute to bleeding. We report a surgical case of a patient with lung cancer concomitant with MDS. CASE PRESENTATION: A 72-year-old man presented to our hospital because of an abnormal shadow on chest x-ray suggesting a primary lung cancer. A peripheral blood smear examination found giant platelets without thrombocytopenia. He was diagnosed with MDS by bone marrow biopsy, and showed defective platelet aggregation despite a normal bleeding time. The patient underwent left lower lobectomy and transfusion of platelets because of chest wall bleeding. CONCLUSIONS: We demonstrated that ordering platelet preparations might be desirable for an MDS patient with defective platelet aggregation who will undergo surgery, even for a normal platelet count and bleeding time. BioMed Central 2018-07-24 /pmc/articles/PMC6057011/ /pubmed/30041670 http://dx.doi.org/10.1186/s13019-018-0777-7 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Koezuka, Satoshi
Hata, Yoshinobu
Otsuka, Hajime
Makino, Takashi
Azuma, Yoko
Azumi, Takashi
Anami, Yoichi
Natori, Kazuhiko
Iyoda, Akira
Lobectomy for lung cancer in a myelodysplastic syndrome patient with decreasing platelet aggregation: report of a case
title Lobectomy for lung cancer in a myelodysplastic syndrome patient with decreasing platelet aggregation: report of a case
title_full Lobectomy for lung cancer in a myelodysplastic syndrome patient with decreasing platelet aggregation: report of a case
title_fullStr Lobectomy for lung cancer in a myelodysplastic syndrome patient with decreasing platelet aggregation: report of a case
title_full_unstemmed Lobectomy for lung cancer in a myelodysplastic syndrome patient with decreasing platelet aggregation: report of a case
title_short Lobectomy for lung cancer in a myelodysplastic syndrome patient with decreasing platelet aggregation: report of a case
title_sort lobectomy for lung cancer in a myelodysplastic syndrome patient with decreasing platelet aggregation: report of a case
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057011/
https://www.ncbi.nlm.nih.gov/pubmed/30041670
http://dx.doi.org/10.1186/s13019-018-0777-7
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