Ajuba inhibits hepatocellular carcinoma cell growth via targeting of β-catenin and YAP signaling and is regulated by E3 ligase Hakai through neddylation

BACKGROUND: Aberrant activation of β-catenin and Yes-associated protein (YAP) signaling pathways has been associated with hepatocellular carcinoma (HCC) progression. The LIM domain protein Ajuba regulates β-catenin and YAP signaling and is implicated in tumorigenesis. However, roles and mechanism of...

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Detalles Bibliográficos
Autores principales: Liu, Min, Jiang, Ke, Lin, Guibin, Liu, Peng, Yan, Yumei, Ye, Tian, Yao, Gang, Barr, Martin P., Liang, Dapeng, Wang, Yang, Gong, Peng, Meng, Songshu, Piao, Haozhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057013/
https://www.ncbi.nlm.nih.gov/pubmed/30041665
http://dx.doi.org/10.1186/s13046-018-0806-3

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