Timing somatic events in the evolution of cancer

Cancer arises through the accumulation of somatic mutations over time. An understanding of the sequence of events during this process should allow both earlier diagnosis and better prediction of cancer progression. However, the pathways of tumor evolution have not yet been comprehensively characteri...

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Detalles Bibliográficos
Autores principales: Jolly, Clemency, Van Loo, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057033/
https://www.ncbi.nlm.nih.gov/pubmed/30041675
http://dx.doi.org/10.1186/s13059-018-1476-3
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author Jolly, Clemency
Van Loo, Peter
author_facet Jolly, Clemency
Van Loo, Peter
author_sort Jolly, Clemency
collection PubMed
description Cancer arises through the accumulation of somatic mutations over time. An understanding of the sequence of events during this process should allow both earlier diagnosis and better prediction of cancer progression. However, the pathways of tumor evolution have not yet been comprehensively characterized. With the advent of whole genome sequencing, it is now possible to infer the evolutionary history of single tumors from the snapshot of their genome taken at diagnosis, giving new insights into the biology of tumorigenesis.
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spelling pubmed-60570332018-07-30 Timing somatic events in the evolution of cancer Jolly, Clemency Van Loo, Peter Genome Biol Review Cancer arises through the accumulation of somatic mutations over time. An understanding of the sequence of events during this process should allow both earlier diagnosis and better prediction of cancer progression. However, the pathways of tumor evolution have not yet been comprehensively characterized. With the advent of whole genome sequencing, it is now possible to infer the evolutionary history of single tumors from the snapshot of their genome taken at diagnosis, giving new insights into the biology of tumorigenesis. BioMed Central 2018-07-24 /pmc/articles/PMC6057033/ /pubmed/30041675 http://dx.doi.org/10.1186/s13059-018-1476-3 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Jolly, Clemency
Van Loo, Peter
Timing somatic events in the evolution of cancer
title Timing somatic events in the evolution of cancer
title_full Timing somatic events in the evolution of cancer
title_fullStr Timing somatic events in the evolution of cancer
title_full_unstemmed Timing somatic events in the evolution of cancer
title_short Timing somatic events in the evolution of cancer
title_sort timing somatic events in the evolution of cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057033/
https://www.ncbi.nlm.nih.gov/pubmed/30041675
http://dx.doi.org/10.1186/s13059-018-1476-3
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