Down Syndrome with Moyamoya Disease: A Case Series

Down syndrome (DS), resulting from trisomy 21, is a common cause of mental retardation. Around 20,000 babies with DS are born every year in India. There is an increased risk of cerebral infarction in children with DS, the common causes being thromboembolism secondary to atrioventricular canal defect...

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Detalles Bibliográficos
Autores principales: Kumar, Pawan, Panigrahi, Inusha, Sankhyan, Naveen, Ahuja, Chirag, Goyadi, Prasoon K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057204/
https://www.ncbi.nlm.nih.gov/pubmed/30090136
http://dx.doi.org/10.4103/jpn.JPN_116_17
Descripción
Sumario:Down syndrome (DS), resulting from trisomy 21, is a common cause of mental retardation. Around 20,000 babies with DS are born every year in India. There is an increased risk of cerebral infarction in children with DS, the common causes being thromboembolism secondary to atrioventricular canal defects, right-to-left shunting, myocardial dysmotility, or cardiac valvular abnormalities. Stroke due to other causes can also occur in patients with DS, and one of these is moyamoya disease. This can be diagnosed by magnetic resonance imaging and/or angiography in these patients. Here we report four cases of moyamoya disease in young patients with DS aged 2–3½ years, of a total of 500 cases with DS registered in the Genetic Clinic.

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