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Down Syndrome with Moyamoya Disease: A Case Series

Down syndrome (DS), resulting from trisomy 21, is a common cause of mental retardation. Around 20,000 babies with DS are born every year in India. There is an increased risk of cerebral infarction in children with DS, the common causes being thromboembolism secondary to atrioventricular canal defect...

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Autores principales: Kumar, Pawan, Panigrahi, Inusha, Sankhyan, Naveen, Ahuja, Chirag, Goyadi, Prasoon K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057204/
https://www.ncbi.nlm.nih.gov/pubmed/30090136
http://dx.doi.org/10.4103/jpn.JPN_116_17
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author Kumar, Pawan
Panigrahi, Inusha
Sankhyan, Naveen
Ahuja, Chirag
Goyadi, Prasoon K.
author_facet Kumar, Pawan
Panigrahi, Inusha
Sankhyan, Naveen
Ahuja, Chirag
Goyadi, Prasoon K.
author_sort Kumar, Pawan
collection PubMed
description Down syndrome (DS), resulting from trisomy 21, is a common cause of mental retardation. Around 20,000 babies with DS are born every year in India. There is an increased risk of cerebral infarction in children with DS, the common causes being thromboembolism secondary to atrioventricular canal defects, right-to-left shunting, myocardial dysmotility, or cardiac valvular abnormalities. Stroke due to other causes can also occur in patients with DS, and one of these is moyamoya disease. This can be diagnosed by magnetic resonance imaging and/or angiography in these patients. Here we report four cases of moyamoya disease in young patients with DS aged 2–3½ years, of a total of 500 cases with DS registered in the Genetic Clinic.
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spelling pubmed-60572042018-08-08 Down Syndrome with Moyamoya Disease: A Case Series Kumar, Pawan Panigrahi, Inusha Sankhyan, Naveen Ahuja, Chirag Goyadi, Prasoon K. J Pediatr Neurosci Case Report Down syndrome (DS), resulting from trisomy 21, is a common cause of mental retardation. Around 20,000 babies with DS are born every year in India. There is an increased risk of cerebral infarction in children with DS, the common causes being thromboembolism secondary to atrioventricular canal defects, right-to-left shunting, myocardial dysmotility, or cardiac valvular abnormalities. Stroke due to other causes can also occur in patients with DS, and one of these is moyamoya disease. This can be diagnosed by magnetic resonance imaging and/or angiography in these patients. Here we report four cases of moyamoya disease in young patients with DS aged 2–3½ years, of a total of 500 cases with DS registered in the Genetic Clinic. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC6057204/ /pubmed/30090136 http://dx.doi.org/10.4103/jpn.JPN_116_17 Text en Copyright: © 2018 Journal of Pediatric Neurosciences http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Kumar, Pawan
Panigrahi, Inusha
Sankhyan, Naveen
Ahuja, Chirag
Goyadi, Prasoon K.
Down Syndrome with Moyamoya Disease: A Case Series
title Down Syndrome with Moyamoya Disease: A Case Series
title_full Down Syndrome with Moyamoya Disease: A Case Series
title_fullStr Down Syndrome with Moyamoya Disease: A Case Series
title_full_unstemmed Down Syndrome with Moyamoya Disease: A Case Series
title_short Down Syndrome with Moyamoya Disease: A Case Series
title_sort down syndrome with moyamoya disease: a case series
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057204/
https://www.ncbi.nlm.nih.gov/pubmed/30090136
http://dx.doi.org/10.4103/jpn.JPN_116_17
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