A copper-mediated reverse aromatic Finkelstein reaction in ionic liquid

We have developed a general method for reverse aromatic Finkelstein reactions. Good reaction yields were obtained when aryl iodides or aryl bromides were treated with copper halide salts as promoters in a 1-butyl-3-methylimidazolium bromide ([BMIM]Br) ionic liquid (IL) solvent at 140 °C for 8 h. Pre...

Descripción completa

Detalles Bibliográficos
Autores principales: Nguyen, Anh T.H., Nguyen, Dat P., Phan, Ngan T.K., Lam, Dung T.T., Phan, Nam T.S., Truong, Thanh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057234/
https://www.ncbi.nlm.nih.gov/pubmed/30046471
http://dx.doi.org/10.1016/j.jare.2017.12.006
Descripción
Sumario:We have developed a general method for reverse aromatic Finkelstein reactions. Good reaction yields were obtained when aryl iodides or aryl bromides were treated with copper halide salts as promoters in a 1-butyl-3-methylimidazolium bromide ([BMIM]Br) ionic liquid (IL) solvent at 140 °C for 8 h. Preliminary investigation supported that the copper salts were also the halide sources in halogen exchange reactions. The optimized conditions are applicable to a variety of substrates and have excellent functional group tolerance. Additionally, the [BMIM]Br solvent showed good stability for at least 10 consecutive runs. Results indicated that the [BMIM]Br solvent was recyclable for reverse aromatic Finkelstein reactions.

Ejemplares similares