Cargando…

Immunomimetic Designer Cells Protect Mice from MRSA Infection

Many community- and hospital-acquired bacterial infections are caused by antibiotic-resistant pathogens. Methicillin-resistant Staphylococcus aureus (MRSA) predisposes humans to invasive infections that are difficult to eradicate. We designed a closed-loop gene network programming mammalian cells to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Ying, Bai, Peng, Woischnig, Anne-Kathrin, Charpin-El Hamri, Ghislaine, Ye, Haifeng, Folcher, Marc, Xie, Mingqi, Khanna, Nina, Fussenegger, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057273/ https://www.ncbi.nlm.nih.gov/pubmed/29937224 http://dx.doi.org/10.1016/j.cell.2018.05.039

Ejemplares similares

Antagonistic control of a dual-input mammalian gene switch by food additives
por: Xie, Mingqi, et al.
Publicado: (2014)

A synthetic biology-based device prevents liver injury in mice
por: Bai, Peng, et al.
Publicado: (2016)

A synthetic free fatty acid-regulated transgene switch in mammalian cells and mice
por: Liu, Ying, et al.
Publicado: (2018)

Self-adjusting synthetic gene circuit for correcting insulin resistance
por: Ye, Haifeng, et al.
Publicado: (2016)

Caffeine-inducible gene switches controlling experimental diabetes
por: Bojar, Daniel, et al.
Publicado: (2018)

A closed-loop synthetic gene circuit for the treatment of diet-induced obesity in mice
por: Rössger, Katrin, et al.
Publicado: (2013)

Design of modular autoproteolytic gene switches responsive to anti-coronavirus drug candidates
por: Franko, Nik, et al.
Publicado: (2021)

Engineering a Rapid Insulin Release System Controlled By Oral Drug Administration
por: Mahameed, Mohamed, et al.
Publicado: (2022)

Synthetic mammalian trigger-controlled bipartite transcription factors
por: Folcher, Marc, et al.
Publicado: (2013)

Controlling therapeutic protein expression via inhalation of a butter flavor molecule
por: Bertschi, Adrian, et al.
Publicado: (2023)

Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment
por: Kojima, Ryosuke, et al.
Publicado: (2018)

5-Fluorouracil blocks quorum-sensing of biofilm-embedded methicillin-resistant Staphylococcus aureus in mice
por: Sedlmayer, Ferdinand, et al.
Publicado: (2021)

Genetically Encoded Protein Thermometer Enables Precise Electrothermal Control of Transgene Expression
por: Stefanov, Bozhidar‐Adrian, et al.
Publicado: (2021)

Cosmetics-triggered percutaneous remote control of transgene expression in mice
por: Wang, Hui, et al.
Publicado: (2015)

A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells
por: Saxena, Pratik, et al.
Publicado: (2016)

Mind-controlled transgene expression by a wireless-powered optogenetic designer cell implant
por: Folcher, Marc, et al.
Publicado: (2014)

Pharmacologically Triggered Hydrogel for Scheduling Hepatitis B Vaccine Administration
por: Gübeli, Raphael J., et al.
Publicado: (2013)

Engineering precision therapies: lessons and motivations from the clinic
por: Xie, Mingqi, et al.
Publicado: (2020)

Identification of Sclareol As a Natural Neuroprotective Ca(v)1.3‐Antagonist Using Synthetic Parkinson‐Mimetic Gene Circuits and Computer‐Aided Drug Discovery
por: Wang, Hui, et al.
Publicado: (2022)

59. Impact of Pharmacist-Led De-Escalation of MRSA Therapy Using MRSA Nasal PCR
por: Salvatus, Marc, et al.
Publicado: (2021)

CP and CP-PGN protect mice against MRSA infection by inducing M1 macrophages
por: Zhang, Yang, et al.
Publicado: (2017)

Engineering autonomous closed-loop designer cells for disease therapy
por: Mahameed, Mohamed, et al.
Publicado: (2022)

MRSA in Practice
por: Elbaz, Wesam
Publicado: (2009)

Emergence of community-associated MRSA (CA-MRSA) in Northern Ireland
por: Loughrey, Anne, et al.
Publicado: (2007)

741. Assessing the Concordance of MRSA Carriage Screening with MRSA Infections
por: Mannheim, Jonathan, et al.
Publicado: (2023)

Therapeutic cell engineering: designing programmable synthetic genetic circuits in mammalian cells
por: Mansouri, Maysam, et al.
Publicado: (2021)

Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses
por: Nguyen, Minh-Thu, et al.
Publicado: (2017)

Use of tilapia piscidin 3 (TP3) to protect against MRSA infection in mice with skin injuries
por: Huang, Han-Ning, et al.
Publicado: (2015)

Micheliolide provides protection of mice against Staphylococcus aureus and MRSA infection by down-regulating inflammatory response
por: Jiang, Xinru, et al.
Publicado: (2017)

Inhibiting PSMα-induced neutrophil necroptosis protects mice with MRSA pneumonia by blocking the agr system
por: Zhou, Ying, et al.
Publicado: (2018)

MRSA screening in emergency department detects a minority of MRSA carriers
por: Mogensen, Christian B, et al.
Publicado: (2015)

CA-MRSA and HA-MRSA coexist in community and hospital settings in Uganda
por: Kateete, David Patrick, et al.
Publicado: (2019)

Biomedically relevant circuit-design strategies in mammalian synthetic biology
por: Bacchus, William, et al.
Publicado: (2013)

Development of Antibacterial Protective Coatings Active against MSSA and MRSA on Biodegradable Polymers
por: Rezić, Iva, et al.
Publicado: (2021)

Orientin mediates protection against MRSA-induced pneumonia by inhibiting Sortase A
por: Wang, Li, et al.
Publicado: (2021)

Quercetin Reduces the Virulence of S. aureus by Targeting ClpP to Protect Mice from MRSA-Induced Lethal Pneumonia
por: Jing, Shisong, et al.
Publicado: (2022)

Detecting Clusters of MRSA
Publicado: (2006)

Seasonality of MRSA Infections
por: Mermel, Leonard A., et al.
Publicado: (2011)

Nasal Decolonisation of MRSA
por: Mantle, Peter
Publicado: (2019)

Controlling hospital MRSA
por: Gould, Ian M.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_7tvg61pso5k8nmsloprnqg3kfa