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Role of Glutathione Redox System on the T-2 Toxin Tolerance of Pheasant (Phasianus colchicus)

The purpose of the present study was to evaluate the effects of different dietary concentrations of T-2 toxin on blood plasma protein content, lipid peroxidation and glutathione redox system of pheasant (Phasianus colchicus). A total of 320 one-day-old female pheasants were randomly assigned to four...

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Autores principales: Fernye, Csaba, Ancsin, Zsolt, Bócsai, Andrea, Balogh, Krisztián, Mézes, Miklós, Erdélyi, Márta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Toxicology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057296/
https://www.ncbi.nlm.nih.gov/pubmed/30057699
http://dx.doi.org/10.5487/TR.2018.34.3.249
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author Fernye, Csaba
Ancsin, Zsolt
Bócsai, Andrea
Balogh, Krisztián
Mézes, Miklós
Erdélyi, Márta
author_facet Fernye, Csaba
Ancsin, Zsolt
Bócsai, Andrea
Balogh, Krisztián
Mézes, Miklós
Erdélyi, Márta
author_sort Fernye, Csaba
collection PubMed
description The purpose of the present study was to evaluate the effects of different dietary concentrations of T-2 toxin on blood plasma protein content, lipid peroxidation and glutathione redox system of pheasant (Phasianus colchicus). A total of 320 one-day-old female pheasants were randomly assigned to four treatment groups fed with a diet contaminated with different concentrations of T-2 toxin (control, 4 mg/kg, 8 mg/kg and 16 mg/kg). Birds were sacrificed at early (12, 24 and 72 hr) and late (1, 2 and 3 weeks) stages of the experiment to demonstrate the effect of T-2 toxin on lipid peroxidation and glutathione redox status in different tissues. Feed refusal and impaired growth were observed with dose dependent manner. Lipid-peroxidation was not induced in the liver, while the glutathione redox system was activated partly in the liver, but primarily in the blood plasma. Glutathione peroxidase activity has changed parallel with reduced glutathione concentration in all tissues. Based on our results, pheasants seem to have higher tolerance to T-2 toxin than other avian species, and glutathione redox system might contribute in some extent to this higher tolerance, in particular against free-radical mediated oxidative damage of tissues, such as liver.
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spelling pubmed-60572962018-07-27 Role of Glutathione Redox System on the T-2 Toxin Tolerance of Pheasant (Phasianus colchicus) Fernye, Csaba Ancsin, Zsolt Bócsai, Andrea Balogh, Krisztián Mézes, Miklós Erdélyi, Márta Toxicol Res Original Article The purpose of the present study was to evaluate the effects of different dietary concentrations of T-2 toxin on blood plasma protein content, lipid peroxidation and glutathione redox system of pheasant (Phasianus colchicus). A total of 320 one-day-old female pheasants were randomly assigned to four treatment groups fed with a diet contaminated with different concentrations of T-2 toxin (control, 4 mg/kg, 8 mg/kg and 16 mg/kg). Birds were sacrificed at early (12, 24 and 72 hr) and late (1, 2 and 3 weeks) stages of the experiment to demonstrate the effect of T-2 toxin on lipid peroxidation and glutathione redox status in different tissues. Feed refusal and impaired growth were observed with dose dependent manner. Lipid-peroxidation was not induced in the liver, while the glutathione redox system was activated partly in the liver, but primarily in the blood plasma. Glutathione peroxidase activity has changed parallel with reduced glutathione concentration in all tissues. Based on our results, pheasants seem to have higher tolerance to T-2 toxin than other avian species, and glutathione redox system might contribute in some extent to this higher tolerance, in particular against free-radical mediated oxidative damage of tissues, such as liver. Korean Society of Toxicology 2018-07 2018-07-15 /pmc/articles/PMC6057296/ /pubmed/30057699 http://dx.doi.org/10.5487/TR.2018.34.3.249 Text en Copyright © 2018 The Korean Society Of Toxicology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Fernye, Csaba
Ancsin, Zsolt
Bócsai, Andrea
Balogh, Krisztián
Mézes, Miklós
Erdélyi, Márta
Role of Glutathione Redox System on the T-2 Toxin Tolerance of Pheasant (Phasianus colchicus)
title Role of Glutathione Redox System on the T-2 Toxin Tolerance of Pheasant (Phasianus colchicus)
title_full Role of Glutathione Redox System on the T-2 Toxin Tolerance of Pheasant (Phasianus colchicus)
title_fullStr Role of Glutathione Redox System on the T-2 Toxin Tolerance of Pheasant (Phasianus colchicus)
title_full_unstemmed Role of Glutathione Redox System on the T-2 Toxin Tolerance of Pheasant (Phasianus colchicus)
title_short Role of Glutathione Redox System on the T-2 Toxin Tolerance of Pheasant (Phasianus colchicus)
title_sort role of glutathione redox system on the t-2 toxin tolerance of pheasant (phasianus colchicus)
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057296/
https://www.ncbi.nlm.nih.gov/pubmed/30057699
http://dx.doi.org/10.5487/TR.2018.34.3.249
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