Cargando…

Piper Essential Oils Inhibit Rhizopus oryzae Growth, Biofilm Formation, and Rhizopuspepsin Activity

Piper is the largest genus of the Piperaceae family. The species of this genus have diverse biological activities and are used in pharmacopeia throughout the world. They are also used in folk medicine for treatment of many diseases in several countries including Brazil, China, India, Jamaica, and Me...

Descripción completa

Detalles Bibliográficos
Autores principales: Almeida, Catia A., Azevedo, Mariana M. B., Chaves, Francisco C. M., Roseo de Oliveira, Marcelo, Rodrigues, Igor A., Bizzo, Humberto R., Gama, Paola E., Alviano, Daniela S., Alviano, Celuta S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057405/
https://www.ncbi.nlm.nih.gov/pubmed/30073039
http://dx.doi.org/10.1155/2018/5295619
_version_ 1783341519799844864
author Almeida, Catia A.
Azevedo, Mariana M. B.
Chaves, Francisco C. M.
Roseo de Oliveira, Marcelo
Rodrigues, Igor A.
Bizzo, Humberto R.
Gama, Paola E.
Alviano, Daniela S.
Alviano, Celuta S.
author_facet Almeida, Catia A.
Azevedo, Mariana M. B.
Chaves, Francisco C. M.
Roseo de Oliveira, Marcelo
Rodrigues, Igor A.
Bizzo, Humberto R.
Gama, Paola E.
Alviano, Daniela S.
Alviano, Celuta S.
author_sort Almeida, Catia A.
collection PubMed
description Piper is the largest genus of the Piperaceae family. The species of this genus have diverse biological activities and are used in pharmacopeia throughout the world. They are also used in folk medicine for treatment of many diseases in several countries including Brazil, China, India, Jamaica, and Mexico. In Brazil, Piper species are distributed throughout the national territory, making this genus a good candidate for biological activity screening. During our studies with Piper essential oils, we evaluated its activity against Rhizopus oryzae, the main agent of mucormycosis. The main compounds of seven Piper essential oils analyzed were Piper callosum—safrole (53.8%), P. aduncum—dillapiole (76.0%), P. hispidinervum—safrole (91.4%), P. marginatum—propiopiperone (13.2%), P. hispidum—γ-terpinene (30.9%), P. tuberculatum—(E)-caryophyllene (30.1%), and Piper sp.—linalool (14.6%). The minimum inhibitory concentration of Piper essential oils against R. oryzae ranged from 78.12 to >1250 μg/mL. The best result of total inhibition of biofilm formation was obtained with Piper sp. starting from 4.88 μg/mL. Considering the bioactive potential of EOs against planktonic cells and biofilm formation of R. oryzae could be of great interest for development of antimicrobials for therapeutic use in treatment of fungal infection.
format Online
Article
Text
id pubmed-6057405
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-60574052018-08-02 Piper Essential Oils Inhibit Rhizopus oryzae Growth, Biofilm Formation, and Rhizopuspepsin Activity Almeida, Catia A. Azevedo, Mariana M. B. Chaves, Francisco C. M. Roseo de Oliveira, Marcelo Rodrigues, Igor A. Bizzo, Humberto R. Gama, Paola E. Alviano, Daniela S. Alviano, Celuta S. Can J Infect Dis Med Microbiol Research Article Piper is the largest genus of the Piperaceae family. The species of this genus have diverse biological activities and are used in pharmacopeia throughout the world. They are also used in folk medicine for treatment of many diseases in several countries including Brazil, China, India, Jamaica, and Mexico. In Brazil, Piper species are distributed throughout the national territory, making this genus a good candidate for biological activity screening. During our studies with Piper essential oils, we evaluated its activity against Rhizopus oryzae, the main agent of mucormycosis. The main compounds of seven Piper essential oils analyzed were Piper callosum—safrole (53.8%), P. aduncum—dillapiole (76.0%), P. hispidinervum—safrole (91.4%), P. marginatum—propiopiperone (13.2%), P. hispidum—γ-terpinene (30.9%), P. tuberculatum—(E)-caryophyllene (30.1%), and Piper sp.—linalool (14.6%). The minimum inhibitory concentration of Piper essential oils against R. oryzae ranged from 78.12 to >1250 μg/mL. The best result of total inhibition of biofilm formation was obtained with Piper sp. starting from 4.88 μg/mL. Considering the bioactive potential of EOs against planktonic cells and biofilm formation of R. oryzae could be of great interest for development of antimicrobials for therapeutic use in treatment of fungal infection. Hindawi 2018-07-05 /pmc/articles/PMC6057405/ /pubmed/30073039 http://dx.doi.org/10.1155/2018/5295619 Text en Copyright © 2018 Catia A. Almeida et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Almeida, Catia A.
Azevedo, Mariana M. B.
Chaves, Francisco C. M.
Roseo de Oliveira, Marcelo
Rodrigues, Igor A.
Bizzo, Humberto R.
Gama, Paola E.
Alviano, Daniela S.
Alviano, Celuta S.
Piper Essential Oils Inhibit Rhizopus oryzae Growth, Biofilm Formation, and Rhizopuspepsin Activity
title Piper Essential Oils Inhibit Rhizopus oryzae Growth, Biofilm Formation, and Rhizopuspepsin Activity
title_full Piper Essential Oils Inhibit Rhizopus oryzae Growth, Biofilm Formation, and Rhizopuspepsin Activity
title_fullStr Piper Essential Oils Inhibit Rhizopus oryzae Growth, Biofilm Formation, and Rhizopuspepsin Activity
title_full_unstemmed Piper Essential Oils Inhibit Rhizopus oryzae Growth, Biofilm Formation, and Rhizopuspepsin Activity
title_short Piper Essential Oils Inhibit Rhizopus oryzae Growth, Biofilm Formation, and Rhizopuspepsin Activity
title_sort piper essential oils inhibit rhizopus oryzae growth, biofilm formation, and rhizopuspepsin activity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057405/
https://www.ncbi.nlm.nih.gov/pubmed/30073039
http://dx.doi.org/10.1155/2018/5295619
work_keys_str_mv AT almeidacatiaa piperessentialoilsinhibitrhizopusoryzaegrowthbiofilmformationandrhizopuspepsinactivity
AT azevedomarianamb piperessentialoilsinhibitrhizopusoryzaegrowthbiofilmformationandrhizopuspepsinactivity
AT chavesfranciscocm piperessentialoilsinhibitrhizopusoryzaegrowthbiofilmformationandrhizopuspepsinactivity
AT roseodeoliveiramarcelo piperessentialoilsinhibitrhizopusoryzaegrowthbiofilmformationandrhizopuspepsinactivity
AT rodriguesigora piperessentialoilsinhibitrhizopusoryzaegrowthbiofilmformationandrhizopuspepsinactivity
AT bizzohumbertor piperessentialoilsinhibitrhizopusoryzaegrowthbiofilmformationandrhizopuspepsinactivity
AT gamapaolae piperessentialoilsinhibitrhizopusoryzaegrowthbiofilmformationandrhizopuspepsinactivity
AT alvianodanielas piperessentialoilsinhibitrhizopusoryzaegrowthbiofilmformationandrhizopuspepsinactivity
AT alvianocelutas piperessentialoilsinhibitrhizopusoryzaegrowthbiofilmformationandrhizopuspepsinactivity