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A mechanism-based computational model to capture the interconnections among epithelial-mesenchymal transition, cancer stem cells and Notch-Jagged signaling

Epithelial-mesenchymal transition (EMT) and cancer stem cell (CSCs) formation are two fundamental and well-studied processes contributing to cancer metastasis and tumor relapse. Cells can undergo a partial EMT to attain a hybrid epithelial/mesenchymal (E/M) phenotype or a complete EMT to attain a me...

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Detalles Bibliográficos
Autores principales:	Bocci, Federico, Jolly, Mohit Kumar, George, Jason Thomas, Levine, Herbert, Onuchic, José Nelson
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057462/ https://www.ncbi.nlm.nih.gov/pubmed/30042822 http://dx.doi.org/10.18632/oncotarget.25692

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