Cargando…

PI3K-Mediated Blimp-1 Activation Controls B Cell Selection and Homeostasis

Activation of phosphoinositide 3-kinase (PI3K) signaling plays a central role in regulating proliferation and survival of B cells. Here, we tested the hypothesis that B cell receptor (BCR)-mediated activation of PI3K induces the terminal differentiation factor Blimp-1 that interferes with proliferat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Setz, Corinna S., Hug, Eva, Khadour, Ahmad, Abdelrasoul, Hend, Bilal, Mayas, Hobeika, Elias, Jumaa, Hassan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057491/ https://www.ncbi.nlm.nih.gov/pubmed/29996100 http://dx.doi.org/10.1016/j.celrep.2018.06.035

Ejemplares similares

PI3K induces B-cell development and regulates B cell identity
por: Abdelrasoul, Hend, et al.
Publicado: (2018)

The Small GTPase RHOA Links SLP65 Activation to PTEN Function in Pre B Cells and Is Essential for the Generation and Survival of Normal and Malignant B Cells
por: Vadakumchery, Anila, et al.
Publicado: (2022)

B-cell antigen receptor expression and phosphatidylinositol 3-kinase signaling regulate genesis and maintenance of mouse chronic lymphocytic leukemia
por: Schmid, Vera Kristin, et al.
Publicado: (2022)

Pten controls B‐cell responsiveness and germinal center reaction by regulating the expression of IgD BCR
por: Setz, Corinna S, et al.
Publicado: (2019)

Autoreactive antibodies control blood glucose by regulating insulin homeostasis
por: Amendt, Timm, et al.
Publicado: (2022)

Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia
por: Abdelrasoul, Hend, et al.
Publicado: (2020)

CCND3 is indispensable for the maintenance of B-cell acute lymphoblastic leukemia
por: Ketzer, Franz, et al.
Publicado: (2022)

The Blimp1–Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis
por: Miyauchi, Yoshiteru, et al.
Publicado: (2010)

Primary Immune Responses and Affinity Maturation Are Controlled by IgD
por: Amendt, Timm, et al.
Publicado: (2021)

Blimp-1 and systemic lupus erythematosus
por: Diamond, Betty, et al.
Publicado: (2014)

Identification of a Pre-BCR Lacking Surrogate Light Chain
por: Su, Yu-wen, et al.
Publicado: (2003)

Tolerogenic function of Blimp-1 in dendritic cells
por: Kim, Sun Jung, et al.
Publicado: (2011)

Tolerogenic function of Blimp-1 in dendritic cells
por: Kim, Sun Jung, et al.
Publicado: (2012)

Selection Study for B+- -> (K-+ pi+- pi-+ pi+-)D K+- and B+- -> (K+ K- pi+ pi-)D K+-".
por: Hunt, P, et al.
Publicado: (2009)

Conserved and Unique Functions of Blimp1 in Immune Cells
por: Nadeau, Samantha, et al.
Publicado: (2022)

Human pointing motion during interaction with an autonomous blimp
por: Hou, Mengxue, et al.
Publicado: (2022)

BLIMP1 Is Required for Postnatal Epidermal Homeostasis but Does Not Define a Sebaceous Gland Progenitor under Steady-State Conditions
por: Kretzschmar, Kai, et al.
Publicado: (2014)

The transcriptional repressor Blimp1 is expressed in rare luminal progenitors and is essential for mammary gland development
por: Ahmed, Mohammed I., et al.
Publicado: (2016)

Blimp1 regulates the transition of neonatal to adult intestinal epithelium
por: Muncan, Vanesa, et al.
Publicado: (2011)

Optimization Problems in the Development of a Monitoring Blimp for FCC-hh
por: Rautela, Vedant
Publicado: (2022)

Blimp-1 Contributes to the Development and Function of Regulatory B Cells
por: Wang, Ying-Hsiu, et al.
Publicado: (2019)

Differential regulation of Effector and Regulatory T cell function by Blimp1
por: Bankoti, Rashmi, et al.
Publicado: (2017)

Blimp-1/PRDM1 is a critical regulator of Type III Interferon responses in mammary epithelial cells
por: Elias, Salah, et al.
Publicado: (2018)

B-1 B lymphocytes require Blimp-1 for immunoglobulin secretion
por: Savitsky, David, et al.
Publicado: (2006)

Plasma Cell Ontogeny Defined by Quantitative Changes in Blimp-1 Expression
por: Kallies, Axel, et al.
Publicado: (2004)

Active repression by Blimp1 play an important role in osteoclast differentiation
por: Nishikawa, Keizo, et al.
Publicado: (2012)

Sirt6 cooperates with Blimp1 to positively regulate osteoclast differentiation
por: Park, So Jeong, et al.
Publicado: (2016)

Mononuclear phagocyte regulation by the transcription factor Blimp‐1 in health and disease
por: Ulmert, Isabel, et al.
Publicado: (2020)

Pax5 Negatively Regulates Osteoclastogenesis through Downregulation of Blimp1
por: Yu, Jiyeon, et al.
Publicado: (2021)

Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow
por: Shapiro-Shelef, Miriam, et al.
Publicado: (2005)

The Germ Cell Determinant Blimp1 Is Not Required for Derivation of Pluripotent Stem Cells
por: Bao, Siqin, et al.
Publicado: (2012)

Role of Blimp-1 in programing Th effector cells into IL-10 producers
por: Neumann, Christian, et al.
Publicado: (2014)

Combinatorial regulation of a Blimp1 (Prdm1) enhancer in the mouse retina
por: Mills, Taylor S., et al.
Publicado: (2017)

Mapping the chromatin landscape and Blimp1 transcriptional targets that regulate trophoblast differentiation
por: Nelson, Andrew C., et al.
Publicado: (2017)

Blimp1(+) cells generate functional mouse sebaceous gland organoids in vitro
por: Feldman, Alona, et al.
Publicado: (2019)

Insights Into the Evolution of the prdm1/Blimp1 Gene Family in Teleost Fish
por: Perdiguero, Pedro, et al.
Publicado: (2020)

BLIMP-1 Mediated Downregulation of TAK1 and p53 Molecules Is Crucial in the Pathogenesis of Kala-Azar
por: Saha, Gundappa, et al.
Publicado: (2020)

Blimp-1 molds the epigenetic architecture of IL-21–mediated autoimmune diseases through an autoregulatory circuit
por: Liu, Yu-Wen, et al.
Publicado: (2022)

Long-lived unipotent Blimp1-positive luminal stem cells drive mammary gland organogenesis throughout adult life
por: Elias, Salah, et al.
Publicado: (2017)

Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma
por: Pasqualucci, Laura, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_3vp8gbnqujgi4o1lr1i0m4ih3n