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ChemDIS 2: an update of chemical-disease inference system
Computational inference of affected functions, pathways and diseases for chemicals could largely accelerate the evaluation of potential effects of chemical exposure on human beings. Previously, we have developed a ChemDIS system utilizing information of interacting targets for chemical-disease infer...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057493/ https://www.ncbi.nlm.nih.gov/pubmed/30053236 http://dx.doi.org/10.1093/database/bay077 |
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author | Tung, Chun-Wei Wang, Shan-Shan |
author_facet | Tung, Chun-Wei Wang, Shan-Shan |
author_sort | Tung, Chun-Wei |
collection | PubMed |
description | Computational inference of affected functions, pathways and diseases for chemicals could largely accelerate the evaluation of potential effects of chemical exposure on human beings. Previously, we have developed a ChemDIS system utilizing information of interacting targets for chemical-disease inference. With the target information, testable hypotheses can be generated for experimental validation. In this work, we present an update of ChemDIS 2 system featured with more updated datasets and several new functions, including (i) custom enrichment analysis function for single omics data; (ii) multi-omics analysis function for joint analysis of multi-omics data; (iii) mixture analysis function for the identification of interaction and overall effects; (iv) web application programming interface (API) for programmed access to ChemDIS 2. The updated ChemDIS 2 system capable of analyzing more than 430 000 chemicals is expected to be useful for both drug development and risk assessment of environmental chemicals. Database URL: ChemDIS 2 is freely accessible via https://cwtung.kmu.edu.tw/chemdis |
format | Online Article Text |
id | pubmed-6057493 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-60574932018-07-27 ChemDIS 2: an update of chemical-disease inference system Tung, Chun-Wei Wang, Shan-Shan Database (Oxford) Database Update Computational inference of affected functions, pathways and diseases for chemicals could largely accelerate the evaluation of potential effects of chemical exposure on human beings. Previously, we have developed a ChemDIS system utilizing information of interacting targets for chemical-disease inference. With the target information, testable hypotheses can be generated for experimental validation. In this work, we present an update of ChemDIS 2 system featured with more updated datasets and several new functions, including (i) custom enrichment analysis function for single omics data; (ii) multi-omics analysis function for joint analysis of multi-omics data; (iii) mixture analysis function for the identification of interaction and overall effects; (iv) web application programming interface (API) for programmed access to ChemDIS 2. The updated ChemDIS 2 system capable of analyzing more than 430 000 chemicals is expected to be useful for both drug development and risk assessment of environmental chemicals. Database URL: ChemDIS 2 is freely accessible via https://cwtung.kmu.edu.tw/chemdis Oxford University Press 2018-07-23 /pmc/articles/PMC6057493/ /pubmed/30053236 http://dx.doi.org/10.1093/database/bay077 Text en © The Author(s) 2018. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Database Update Tung, Chun-Wei Wang, Shan-Shan ChemDIS 2: an update of chemical-disease inference system |
title | ChemDIS 2: an update of chemical-disease inference system |
title_full | ChemDIS 2: an update of chemical-disease inference system |
title_fullStr | ChemDIS 2: an update of chemical-disease inference system |
title_full_unstemmed | ChemDIS 2: an update of chemical-disease inference system |
title_short | ChemDIS 2: an update of chemical-disease inference system |
title_sort | chemdis 2: an update of chemical-disease inference system |
topic | Database Update |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057493/ https://www.ncbi.nlm.nih.gov/pubmed/30053236 http://dx.doi.org/10.1093/database/bay077 |
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