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ChemDIS 2: an update of chemical-disease inference system

Computational inference of affected functions, pathways and diseases for chemicals could largely accelerate the evaluation of potential effects of chemical exposure on human beings. Previously, we have developed a ChemDIS system utilizing information of interacting targets for chemical-disease infer...

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Detalles Bibliográficos
Autores principales: Tung, Chun-Wei, Wang, Shan-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057493/
https://www.ncbi.nlm.nih.gov/pubmed/30053236
http://dx.doi.org/10.1093/database/bay077
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author Tung, Chun-Wei
Wang, Shan-Shan
author_facet Tung, Chun-Wei
Wang, Shan-Shan
author_sort Tung, Chun-Wei
collection PubMed
description Computational inference of affected functions, pathways and diseases for chemicals could largely accelerate the evaluation of potential effects of chemical exposure on human beings. Previously, we have developed a ChemDIS system utilizing information of interacting targets for chemical-disease inference. With the target information, testable hypotheses can be generated for experimental validation. In this work, we present an update of ChemDIS 2 system featured with more updated datasets and several new functions, including (i) custom enrichment analysis function for single omics data; (ii) multi-omics analysis function for joint analysis of multi-omics data; (iii) mixture analysis function for the identification of interaction and overall effects; (iv) web application programming interface (API) for programmed access to ChemDIS 2. The updated ChemDIS 2 system capable of analyzing more than 430 000 chemicals is expected to be useful for both drug development and risk assessment of environmental chemicals. Database URL: ChemDIS 2 is freely accessible via https://cwtung.kmu.edu.tw/chemdis
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spelling pubmed-60574932018-07-27 ChemDIS 2: an update of chemical-disease inference system Tung, Chun-Wei Wang, Shan-Shan Database (Oxford) Database Update Computational inference of affected functions, pathways and diseases for chemicals could largely accelerate the evaluation of potential effects of chemical exposure on human beings. Previously, we have developed a ChemDIS system utilizing information of interacting targets for chemical-disease inference. With the target information, testable hypotheses can be generated for experimental validation. In this work, we present an update of ChemDIS 2 system featured with more updated datasets and several new functions, including (i) custom enrichment analysis function for single omics data; (ii) multi-omics analysis function for joint analysis of multi-omics data; (iii) mixture analysis function for the identification of interaction and overall effects; (iv) web application programming interface (API) for programmed access to ChemDIS 2. The updated ChemDIS 2 system capable of analyzing more than 430 000 chemicals is expected to be useful for both drug development and risk assessment of environmental chemicals. Database URL: ChemDIS 2 is freely accessible via https://cwtung.kmu.edu.tw/chemdis Oxford University Press 2018-07-23 /pmc/articles/PMC6057493/ /pubmed/30053236 http://dx.doi.org/10.1093/database/bay077 Text en © The Author(s) 2018. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Database Update
Tung, Chun-Wei
Wang, Shan-Shan
ChemDIS 2: an update of chemical-disease inference system
title ChemDIS 2: an update of chemical-disease inference system
title_full ChemDIS 2: an update of chemical-disease inference system
title_fullStr ChemDIS 2: an update of chemical-disease inference system
title_full_unstemmed ChemDIS 2: an update of chemical-disease inference system
title_short ChemDIS 2: an update of chemical-disease inference system
title_sort chemdis 2: an update of chemical-disease inference system
topic Database Update
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057493/
https://www.ncbi.nlm.nih.gov/pubmed/30053236
http://dx.doi.org/10.1093/database/bay077
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